Cutaneous head and neck melanoma (CHNM): A population-based study of the prognostic impact of tumor location - 15/10/16
, Trude Eid Robsahm, PhD b, Linda Vos, PhD b, Syed Mohammad Husain Rizvi, MD a, Lars Andreas Akslen, MD, PhD c, d, Marit Bragelien Veierød, PhD eAbstract |
Background |
Most studies of cutaneous head and neck melanomas (CHNM) have reported poorer survival in CHNM compared with other sites, especially on the scalp/neck.
Objective |
We sought to compare patient and tumor characteristics between CHNM and cutaneous trunk and extremity melanomas and between CHNM locations (face/ear vs scalp/neck, anterior vs posterior), and to study prognostic factors in patients with CHNM.
Methods |
We studied all CHNM (n = 1074) from 8120 cases of cutaneous melanomas diagnosed in Norway in 2008 to 2012.
Results |
Compared with cutaneous trunk and extremity melanomas, CHNM were more frequently found in men, more often nodular and lentigo maligna cutaneous melanomas, and diagnosed at higher T stage (P ≤ .01). CHNM located on posterior sites were diagnosed at significantly higher T stage, and were significantly more often diagnosed with ulceration and at more advanced stage compared with CHNM located on anterior sites (P < .001). T stage and clinical stage were the only significant prognostic factors for melanoma-specific and overall death in the multivariable analysis (P < .001).
Limitations |
Low number of cases and the relatively high frequency of missing values are limitations.
Conclusion |
More advanced CHNM were diagnosed on posterior compared with anterior locations, but location was not a significant prognostic factor for cutaneous melanoma–specific or overall death in the multivariable models.
Le texte complet de cet article est disponible en PDF.Key words : head and neck melanoma, mortality, population-based, prognostic factors, scalp/neck location, visibility
Abbreviations used : CHNM, CI, CM, CTEM, HR, LMM, NM, SEER
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 75 - N° 5
P. 975 - novembre 2016 Retour au numéro
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