Imaging mass spectrometry assists in the classification of diagnostically challenging atypical Spitzoid neoplasms - 14/11/16
Abstract |
Background |
Previously, using imaging mass spectrometry (IMS), we discovered proteomic differences between Spitz nevi and Spitzoid melanomas.
Objective |
We sought to determine whether IMS can assist in the classification of diagnostically challenging atypical Spitzoid neoplasms (ASN), to compare and correlate the IMS and histopathological diagnoses with clinical behavior.
Methods |
We conducted a retrospective collaborative study involving centers from 11 countries and 11 US institutions analyzing 102 ASNs by IMS. Patients were divided into clinical groups 1 to 4 representing best to worst clinical behavior. The association among IMS findings, histopathological diagnoses, and clinical groups was assessed.
Results |
There was a strong association between a diagnosis of Spitzoid melanoma by IMS and lesions categorized as clinical groups 2, 3, and 4 (recurrence of disease, metastases, or death) compared with clinical group 1 (no recurrence or metastasis beyond a sentinel node) (P < .0001). Older age and greater tumor thickness were strongly associated with poorer outcome (P = .01).
Conclusions |
IMS diagnosis of ASN better predicted clinical outcome than histopathology. Diagnosis of Spitzoid melanoma by IMS was strongly associated with aggressive clinical behavior. IMS analysis using a proteomic signature may improve the diagnosis and prediction of outcome/risk stratification for patients with ASN.
Le texte complet de cet article est disponible en PDF.Key words : atypical Spitzoid neoplasm, histopathology, imaging mass spectrometry, mass spectrometry, Spitz nevus, Spitzoid melanoma
Abbreviations used : AJCC, ANED, ASN, IMS, SLN, SM, SN
Plan
Supported in part by a grant: National Institutes of Health/National Institute of General Medical Sciences NIH/NIGMS 5P41 GM103391-05. |
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Conflicts of interest: None declared. |
Vol 75 - N° 6
P. 1176 - décembre 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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