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Archives of cardiovascular diseases
Volume 110, n° 2
pages 106-115 (février 2017)
Doi : 10.1016/j.acvd.2016.05.008
Received : 8 September 2015 ;  accepted : 18 May 2016
Downhill exercise training in monocrotaline-injected rats: Effects on echocardiographic and haemodynamic variables and survival
Entraînement en mode excentrique des rats monocrotaline : effets sur la survie, les paramètres échocardiographiques et hémodynamiques
 

Figure 1




Figure 1 : 

Study design. Eccentric (ECC) training started 2 weeks after injection. The delay between the third echocardiograph and sacrifice was 5–7 days. 2w, 3w, 4w, 5w and 6w: 2, 3, 4, 5 and 6 weeks after injection, respectively; CL: control rats; CLecc: eccentric-trained control rats; CLsed: sedentary control rats; Echo: echocardiographic evaluation; Max speed: maximal eccentric speed based on an incremental running test; MT: monocrotaline-injected rats; MTecc: monocrotaline-injected eccentric-trained rats; MTsed: monocrotaline-injected sedentary rats; RVcath: right ventricular catheterization.


Figure 2




Figure 2 : 

Survival analysis. No significant difference was observed between monocrotaline-injected eccentric-trained rats (MTecc) and monocrotaline-injected sedentary rats (MTsed). CLecc: eccentric-trained control rats; CLsed: sedentary control rats.


Figure 3




Figure 3 : 

Echocardiographic variables. These data were recorded in rats that completed the three echocardiographic evaluations. 2w, 4w and 6w: 2, 4 and 6 weeks after injection, respectively; CLecc: eccentric-trained control rats; CLsed: sedentary control rats; MTecc: monocrotaline-injected eccentric-trained rats; LV: left ventricle; MTsed: monocrotaline-injected sedentary rats; PAAT: pulmonary artery acceleration time; RV: right ventricle; RV EDD: right ventricular end-diastolic diameter; SV: stroke volume; TAPSE: tricuspid annular plane systolic excursion. **P <0.01 for monocrotaline-injected versus control rats. ***P <0.001 for monocrotaline-injected versus control rats. $$P <0.01 for monocrotaline-injected rats at 4wk versus 2wk and 6wk versus 2wk. $$$P <0.001 monocrotaline-injected rats at 4wk versus 2wk and 6wk versus 2wk. #P <0.05 for monocrotaline-injected rats at 6wk versus 4wk. ##P <0.01 for monocrotaline-injected rats at 6wk versus 4wk.


Figure 4




Figure 4 : 

Eccentric maximal speed (%) at 2 weeks (2wk), 4 weeks (4wk) and 6 weeks (6wk) after injection. These data were recorded in the rats that completed the three exercise tests. CLecc: eccentric-trained control rats; CLsed: sedentary control rats; MTecc: monocrotaline-injected eccentric-trained rats; MTsed: monocrotaline-injected sedentary rats. ***P <0.001 for monocrotaline-injected versus control rats. £P <0.05 for CLecc versus CLsed. §P <0.05 for MTecc vs MTsed.


Figure 5




Figure 5 : 

Right ventricular systolic pressure (RVSP) measured during RV catheterization at the end of the study. CLecc: eccentric-trained control rats; CLsed: sedentary control rats; MTecc: monocrotaline-injected eccentric-trained rats; MTsed: monocrotaline-injected sedentary rats. ***P <0.001 for monocrotaline-injected versus control rats.

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