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Journal Français d'Ophtalmologie
Volume 40, n° 4
pages 303-313 (avril 2017)
Doi : 10.1016/j.jfo.2016.11.009
Received : 13 September 2016 ;  accepted : 19 November 2016
Macular pigment density variation after supplementation of lutein and zeaxanthin using the Visucam® 200 pigment module: Impact of age-related macular degeneration and lens status
Densité optique du pigment maculaire après supplémentation en lutéine et zéaxanthine grâce au module pigment du Visucam® 200 : impact de l’état du cristallin et de la dégénérescence maculaire liée à l’âge

Figure 1

Figure 1 : 

Baseline macular pigment optical density (MPOD) pattern as measured with the Visucam® 200 in a pseudophakic patient at the time of inclusion. Four MPOD parameters were taken at every measurement: volume (sum of all OD in the area), area (area where macular pigments could be detected), max OD (maximum value of OD in the area) and mean OD (mean value of OD in the area).

Figure 2

Figure 2 : 

Time course of macular pigment optical density (MPOD) at baseline (visit 0), during an 8-months supplementation either with () or without () carotenoids (visit 1 to 4), and after supplementation withdrawal (visit 5 and 6), expressed in Density Units (D.U.). Continuous lines: Group A (patients without any retinal pathology who underwent cataract surgery 1 month previously, followed on the operated eye). Dashed lines: Group B (patients with exudative age-related macular degeneration in only one eye, followed on the non-exudative eye).

Figure 3

Figure 3 : 

Distribution of macular pigment optical density (MPOD) in phakic and pseudophakic patients of Group B, at the visit of inclusion (V0 MPOD) (Fig. 3A) and at visit 4 (V4 MPOD), which corresponds to the end of supplementation (Fig. 3B). Phakic patients tended to have a significantly higher MPOD levels than pseudophakic patients at both visits (P <0.001).

Figure 4

Figure 4 : 

Scatterplots and regression lines depicting the correlations between baseline macular pigment optical density (MPOD) and age, in both phakic patients and all pseudophakic patients. A strong positive correlation was found between baseline MPOD and age in phakic patients (P <0.001), whereas no significant correlation was found in pseudophakic patients (P =0.3).

Figure 5

Figure 5 : 

Distribution of macular pigment optical density (MPOD) in Group A (pseudophakic patients without any retinal pathology) and in pseudophakic patients of Group B, at the visit of inclusion (V0 MPOD) (Fig. 5A) and at visit 4 (V4 MPOD), which corresponds to the end of supplementation (Fig. 5B). MPOD levels tended to be significantly lower in Group A compared to pseudophakic patients of Group B at both visits (P <0.05).

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