Clustering of autoimmune diseases in patients with rosacea - 18/04/17
Abstract |
Background |
Rosacea is a common inflammatory skin condition that shares genetic risk loci with autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease. A recent genomewide association study identified 90 genetic regions associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, respectively. However, a possible association with rosacea was not investigated.
Objective |
We evaluated the association between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively.
Methods |
We performed a population-based case-control study. A total of 6759 patients with rosacea were identified and matched with 33,795 control subjects on age, sex, and calendar time. We used conditional logistic regression to calculate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).
Results |
After adjustment for smoking and socioeconomic status, patients with rosacea had significantly increased ORs for T1DM (OR 2.59, 95% CI 1.41-4.73), celiac disease (OR 2.03, 95% CI 1.35-3.07), multiple sclerosis (OR 1.65, 95% CI 1.20-2.28), and rheumatoid arthritis (OR 2.14, 95% CI 1.82-2.52). The association was mainly observed in women.
Limitations |
We were unable to distinguish between the different subtypes and severities of rosacea.
Conclusions |
Rosacea is associated with T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively, in women, whereas the association in men only reached statistical significance for rheumatoid arthritis.
Le texte complet de cet article est disponible en PDF.Key words : celiac disease, diabetes, epidemiology, multiple sclerosis, rheumatoid arthritis, rosacea
Abbreviations used : CI, GWAS, ICD-8, ICD-10, OR, SLE, T1DM
Plan
Funding sources: None. |
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Disclosure: Dr Hansen is supported by a grant from the LEO Foundation. Dr Gislason is supported by an unrestricted research scholarship from the Novo Nordisk Foundation. Dr Egeberg is currently employed by Pfizer. Dr Thyssen is supported by a grant from the Lundbeck Foundation. This research was performed independently through the authors' academic university affiliations. |
Vol 74 - N° 4
P. 667 - avril 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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