Risk factors and outcomes of cutaneous melanoma in women less than 50 years of age - 18/04/17
Abstract |
Background |
Melanoma is the fifth most common cancer in the United States, with recent reports indicating increasing incidence among young women.
Objective |
This study sought to investigate histopathology, staging, risk factors, and outcomes of cutaneous melanoma in women younger than 50 years.
Methods |
All female patients aged up to 49 years with biopsy-proven diagnosis of melanoma between 1988 and 2012 were included. Patients with a follow-up of less than 2 years were excluded.
Results |
A total of 462 patients were identified, with mean age of 34.7 years. Invasive melanoma was less common in women 19 years of age or younger (P < .0008). Positive sentinel node status (P < .008), recurrence rates, metastatic disease (P < .001), and death rates (P < .008) were higher for women ages 40 to 49 years. The 41 patients with a pregnancy-associated melanoma had a significantly worse prognosis in comparison with a control group of nonpregnant patients, with a 9-fold increase in recurrence (P < .001), 7-fold increase in metastasis (P = .03) and 5-fold increase in mortality (P = .06).
Limitations |
This was a retrospective study.
Conclusion |
The increasing incidence of melanoma for women younger than 50 years suggests that regular skin checks and self-examinations are warranted. In addition, in women given the diagnosis of melanoma during or within 1 year after childbirth, regular follow-up and monitoring for recurrence are recommended.
Le texte complet de cet article est disponible en PDF.Key words : melanoma, pregnancy, pregnancy-associated melanoma, outcomes, sentinel node, survival, young
Abbreviations used : AJCC, MM, PAMM
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 74 - N° 4
P. 731-738 - avril 2016 Retour au numéro
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