Prevention and management of glucocorticoid-induced side effects: A comprehensive review : Infectious complications and vaccination recommendations - 18/04/17

Doi : 10.1016/j.jaad.2016.02.1240

Avrom Caplan, MD ^a,^c, Nicole Fett, MD ^b, Misha Rosenbach, MD ^a,^c, Victoria P. Werth, MD ^a,^c, Robert G. Micheletti, MD ^a,^c,^⁎
^a Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
^c Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania
^b Department of Dermatology, Oregon Health and Science University, Portland, Oregon

^∗Correspondence to: Robert G. Micheletti, MD, Departments of Dermatology and Medicine, University of Pennsylvania, 2 Maloney Bldg, 3400 Spruce St, Philadelphia, PA 19107.Departments of Dermatology and MedicineUniversity of Pennsylvania2 Maloney Bldg, 3400 Spruce StPhiladelphiaPA19107

Abstract

Part 3 of this 4-part continuing medical education series reviews several important infectious complications of corticosteroid use, including a focus on pneumocystis pneumonia (PCP) prophylaxis, tuberculosis, viral hepatitis, and other infections, followed by a discussion of vaccination recommendations in immunosuppressed patients.

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Key words : glucocorticoids, infections, pneumocystis pneumonia, side effects, steroids, vaccines

Plan

Glucocorticoids and immunity

Pneumocystis pneumonia prophlaxis

Overview

Estimating risk

Prophylactic regimens

Other infections

Tuberculosis

Strongyloides hyperinfection syndrome

Hepatitis B and C viruses

Vaccination recommendations

Influenza and pneumococcus

Other vaccines

	Funding sources: None.
	Conflicts of interest: None declared.
	Please note that bone health and gastrointestinal and endocrinologic side effects of glucocorticoid were discussed in the first two installments of this Continuing Medical Education feature in the January 2017 issue of the JAAD.
	Date of release: February 2017
	Expiration date: February 2020