Mortality burden and prognosis of thin melanomas overall and by subcategory of thickness, SEER registry data, 1992-2013 - 18/04/17
Abstract |
Background |
Thin melanomas cause a high death toll despite excellent prognosis.
Objective |
We examined melanoma mortality burden and prognosis by categories of thickness within Surveillance, Epidemiology, and End Results (SEER) 13 Registry 1992-2013.
Methods |
We divided 49,319 stage I and II melanoma cases diagnosed between 1992 and 2003 into T1 through T4 and then subdivided T1 into 0.01-0.25 mm, 0.26-0.50 mm, 0.51-0.75 mm, and 0.76-1.00 mm categories. We determined the number and proportion of deaths due to melanoma within 10 years of diagnosis for each thickness category and proportions within T1 subcategories with ulceration.
Results |
We confirmed prognosis worsened as melanoma thickened from T1 to T4; however, most deaths resulted from melanomas that were diagnosed at the T1 stage. The smallest number of deaths within T1 resulted from 0.01-0.25 mm–thick melanomas; however, the risk for death within 10 years was greater for those diagnosed with melanoma when tumor depth was 0.01-0.25 mm than for those diagnosed when tumor depth was 0.26-0.50 mm. Prognosis worsened with depths starting at 0.51 mm. The pattern within T1 was not explained by ulceration.
Limitations |
We did not evaluate melanoma subtype, mitotic rate, or other associated features.
Conclusion |
Thin melanomas are a substantial public health burden. Efforts should be made to diagnose melanoma at the in situ stage.
Le texte complet de cet article est disponible en PDF.Key words : diagnosis, early detection, melanoma, melanoma mortality, melanoma prognosis, SEER, T1 melanoma, thin melanoma, ulceration
Abbreviations used : AJCC, CI, EOD, SEER
Plan
Funding source: None. |
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Conflicts of interest: None declared. |
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Previously presented: Society for Investigative Dermatology meeting abstract, Scottsdale, Arizona, May 11-14, 2016. |
Vol 76 - N° 2
P. 258-263 - février 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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