Development and validation of a patient-reported outcome measure in vitiligo: The Self Assessment Vitiligo Extent Score (SA-VES) - 18/04/17
, Janny E. Lommerts, MD b, Marcel W. Bekkenk, MD, PhD b, Cecilia A.C. Prinsen, MD, PhD c, Viktoria Eleftheriadou, MD, PhD d, Alain Taieb, MD, PhD e, Mauro Picardo, MD, PhD f, Khaled Ezzedine, MD, PhD g, Albert Wolkerstorfer, MD, PhD b, Reinhart Speeckaert, MD, PhD aon behalf of the
international Vitiligo Score Working Group
Abstract |
Background |
The Vitiligo Extent Score (VES) has recently been introduced as a physicians' score for the clinical assessment of the extent of vitiligo, but a good patient self-assessment score is lacking.
Objective |
The objective is to develop and validate a simplified version of the VES as a patient-reported outcome measure (PROM).
Methods |
After extensive pilot testing, patients were asked to score their vitiligo extent twice with an interval of 2 weeks using the Self Assessment Vitiligo Extent Score (SA-VES). The scores were compared with the physicians' evaluation (VES).
Results |
The SA-VES demonstrated very good test-retest reliability (intraclass correlation = 0.948, 95% confidence interval [CI]: 0.911-0.970) that was not affected by age, skin type, or vitiligo distribution pattern. According to patients, this evaluation method was easy to use (22% very easy; 49% easy; 29% normal) and required <5 minutes in the majority of patients (73%, <5 minutes; 24%, 5-10 minutes; 2%, 10-15 minutes). Comparison of the SA-VES and the VES demonstrated excellent correlation (r = 0.986, P <.001).
Limitations |
Few patients had a dark skin type.
Conclusion |
The results demonstrate excellent reliability of the SA-VES and excellent correlation with its investigator-reported counterpart (VES). This patient-oriented evaluation method provides a useful tool for the assessment of vitiligo extent.
Le texte complet de cet article est disponible en PDF.Key words : body surface area, outcome measurement, patient-reported outcomes, severity, vitiligo
Abbreviations used : BSA, COSMIN, ICC, IQR, PROM, SA-VES, SDC, SEM, VASI, VES
Plan
| Supported by the EADV (approved Project Proposal n°2015-030). The research activities of the principle investigator N. van Geel are supported by the Scientific Research Foundation-Flanders (FWO Senior Clinical Investigator: 1831512N) and of R. Speeckaert by postdoctoral research grant (01P12914) from the Ghent University Special Research Fund. |
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| Drs van Geel and Lommerts contributed equally. |
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| Conflicts of interest: None declared. |
Vol 76 - N° 3
P. 464-471 - mars 2017 Retour au numéro
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