Increased risk of avascular necrosis in patients with psoriatic disease: A nationwide population-based matched cohort study - 18/04/17
Abstract |
Background |
Avascular necrosis (AVN) and psoriasis have some pathogenic mechanisms and associated conditions in common.
Objective |
To examine the association between psoriasis and AVN.
Methods |
This study used data from the Taiwan National Health Insurance Research Database for the period 2004–2006 and identified 28,268 patients with psoriasis, who were then matched for age and sex with 113,072 controls without psoriasis from the Taiwan Longitudinal Health Insurance Database 2000. Multivariate Cox proportional hazards models were used for the analysis.
Results |
The unadjusted risk of AVN was significantly higher for patients with psoriasis than for controls (hazard ratio [HR] 2.29) and remained significant after adjustment for other risk factors (adjusted HR 1.96; 95% confidence interval 1.62-2.38). The risk for AVN increased in relation to psoriasis severity and was higher for patients with psoriasis and arthritis than for patients without arthritis. The adjusted HRs were higher for male patients than for female patients and for patients younger than 30 years compared with older patients.
Limitations |
We lacked information on daily tobacco use, alcohol consumption, and physical activity.
Conclusion |
The risk for AVN increased with the disease severity of psoriasis.
Le texte complet de cet article est disponible en PDF.Key words : avascular necrosis, comorbidities, inflammation, National Health Insurance Research Database, osteonecrosis, psoriasis
Abbreviations used : aHR, AVN, CI, DDD, HR, ICD-9-CM, NHIRD, PsA, SLE
Plan
| Funding source: Supported by a grant from the Ministry of Science and Technology, Taiwan (formerly, the National Science Council; grant numbers, MOST104-2314-B-002-117-MY3), which follows the guidelines on good publication practice. The study authors designed the study, collected and analyzed the data, interpreted the results, and wrote the manuscript independent of the funders. |
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| Conflicts of interest: Dr Tsen-Fang Tsai has conducted clinical trials and received honoraria as a consultant for Pfizer Pharmaceuticals, Serono International SA (now Merck Serono International), UniPharma/Biogen Idec, Galderma, Celgene, Novartis Pharmaceuticals, and Janssen-Cilag Pharmaceutical and has received speaking fees from AbbVie. Dr Chiu has received speaking fees from AbbVie, Janssen-Cilag Pharmaceutical, and Pfizer. The other authors have no conflicts of interest to declare. |
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| Dr Chiu and Ms Wang contributed equally. |
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| Dr Shiu contributed equally to the corresponding authorship. |
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| Reprints not available from the authors. |
Vol 76 - N° 5
P. 903 - mai 2017 Retour au numéro
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