Cystic lung disease in Sjögren's syndrome: An observational study - 27/04/17

Doi : 10.1016/j.jbspin.2016.05.019

Sarah Lechtman ^a, Marie-Pierre Debray ^b, Bruno Crestani ^c,^d, Catherine Bancal ^e, Muriel Hourseau ^f, Antoine Dossier ^a, Jean-François Alexandra ^a, Marie-Paule Chauveheid ^a, Thomas Papo ^a,^d,^g, Karim Sacre ^a,^d,^g,^⁎
^a Département de médecine interne, hôpital Bichat, université Paris Diderot, PRES Sorbonne Paris Cité, Assistance publique–Hôpitaux de Paris, 75018 Paris, France
^b Département de radiologie, hôpital Bichat, université Paris Diderot, PRES Sorbonne Paris Cité, Assistance publique–Hôpitaux de Paris, 75018 Paris, France
^c Département de pneumologie, hôpital Bichat, université Paris Diderot, PRES Sorbonne Paris Cité, Assistance publique–Hôpitaux de Paris, 75018 Paris, France
^d Département hospitalo-universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), université Paris Diderot, PRES Sorbonne Paris Cité, 75018 Paris, France
^e Département de physiologie, hôpital Bichat, université Paris Diderot, PRES Sorbonne Paris Cité, Assistance publique–Hôpitaux de Paris, 75018 Paris, France
^f Département de pathologie, hôpital Bichat, université Paris Diderot, PRES Sorbonne Paris Cité, Assistance publique–Hôpitaux de Paris, 75018 Paris, France
^g Inserm U1149, université Paris Diderot, laboratoire d’excellence INFLAMEX, PRES Sorbonne Paris Cité, Paris, France

^⁎Corresponding author. Department of Internal Medicine, Assistance publique–Hôpitaux de Paris, University Paris Diderot, 46, rue Henri-Huchard, 75018 Paris, France.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

pages	5
Iconographies	0
Vidéos	0
Autres	0

Abstract

Objectives

To analyze the prevalence, characteristics and outcome of cystic lung disease associated with Sjögren's syndrome (SS).

Methods

From June 2010 to February 2015, 90 consecutive SS patients [60.1±14.8years; 88 (97.8%) female, 75 (83.3%) primary SS] had a systematic chest CT-scan. The presence of thin-walled cysts was analyzed by one experienced radiologist. Demographic data, clinical history, laboratory findings, and pulmonary function tests were extracted retrospectively from medical records.

Results

Twenty-one (23.3%) patients had cysts on CT scan performed 40.5±54.5months after SS diagnosis. Cysts number ranged from 1 to 25 were often bilateral (52.4%) and mostly located in the middle lung zone (76.2%). Cysts were isolated (n=6, 28.6%) or associated with other lesions, including bronchiectasis (n=5, 23.8%), micronodules (n=5, 23.8%), ground-glass opacity (n=4, 19%) and/or air trapping (n=3, 14.3%). Most patients with cysts (57.1%) had no respiratory symptoms. When comparing SS patients with and without cysts, patients with cysts tended to be older (65.3±15.3 versus 58.5±14.4years, P=0.06). Smoking habits were similar in both groups. Anti-SSB antibodies were more frequently detected in patients with cysts (57.1% vs. 26.1%, P=0.02). Pulmonary function tests were normal or displayed only mild small airways obstruction and reduced diffusion capacity to carbon monoxide. Four (19%) patients with cysts had a past history of associated pulmonary disease, including interstitial lung disease. During follow-up (25.1±17.7months), no patient developed specific lung disease or lymphoproliferative disorders.

Conclusions

Cystic lung disease is frequent, benign, associated with anti-SSB/La antibodies and has no impact on outcome in SS.

Le texte complet de cet article est disponible en PDF.

Keywords : Sjogren's syndrome, Cystic disease of lung, SSB antigen

Plan

Radiological analysis

Statistical analysis

Results

Characteristics of patients

Cystic lung disease

Clinical significance of cystic lung disease and impact on outcome

Discussion

Disclosure of interest

Export

Vol 84 - N° 3

P. 317-321 - mai 2017 Retour au numéro

Article précédent

Serum levels of Dkk-1, sclerostin and VEGF in patients with ankylosing spondylitis and their association with smoking, and clinical, inflammatory and radiographic parameters
Grigorios T. Sakellariou, Alexios Iliopoulos, Maria Konsta, Eustathios Kenanidis, Michael Potoupnis, Eleftherios Tsiridis, Elpida Gavana, Fares E. Sayegh

| Article suivant

Venous thrombosis in patients with giant cell arteritis: Features and outcomes in a cohort study
Kim Heang Ly, Eric Liozon, François Dalmay, Guillaume Gondran, Sylvain Palat, Holy Bézanahary, François-Xavier Lapébie, Anne Cypierre, Sylvie Nadalon, Pierre-Marie Preux, Anne-Laure Fauchais

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Cystic lung disease in Sjögren's syndrome: An observational study - 27/04/17

Abstract

Objectives

Methods

Results

Conclusions

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL