Article

Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

  • You can purchase this item in Pay Per ViewPay per View - FAQ : 33,00 € Taxes included to order
    Pages Iconography Videos Other
    13 0 0 0


Nutrition clinique et métabolisme
Volume 15, n° 4
pages 273-285 (décembre 2001)
Modèles animaux pour les études métaboliques et nutritionnelles lors de la croissance tumorale
Animal models of tumor growth for metabolic and nutritional studies

Thierry  Le Bricon a * ,  Lindsay  Robinson b ,  Vickie E.  Baracos c
aLaboratoire de biochimie A, hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75010 Paris, France 
bdepartment of human biology and nutritional sciences, university of Guelph, Guelph, Ontario, ON N1G 2W1, Canada 
cdepartment of agricultural, food and nutritional science, university of Alberta, 3-18G Agric Forestry, Edmonton, Alberta, AB T6G 2P5, Canada 

*Correspondance et tirés à part.
@@#100979@@

Par leur diversité, les modèles animaux permettent d'approcher la complexité de la dénutrition cancéreuse. Les tumeurs animales transplantables ont été très utilisées, malgré une masse tumorale élevée et l'absence de thérapeutique antitumorale. Les rares études ayant utilisé un traitement (chimiothérapie ou chirurgie) suggèrent que la dénutrition est le résultat de processus liés à la tumeur (détournement de substrats, sécrétion de facteurs cataboliques, modification de l'environnement hormonal), aux traitements anti-néoplasiques agressifs ou d'une interaction entre les deux. Aujourd'hui, l'intervention nutritionnelle vise à optimiser la balance entre l'hôte et la tumeur en utilisant, par exemple, des régimes semi-purifiés avec apport de pharmaconutriments azotés (glutamine, arginine) ou d'acides gras polyinsaturés de la série n-3. Un effort de modélisation reste nécessaire afin de développer des modèles mieux adaptés à la réalité clinique et permettant d'améliorer la prise en charge du patient cancéreux.

Mots clés  : acides aminés ; acides gras ; chimiothérapie ; nutrition ; tumeur.

Abstract

Diverse animal models have been used to model the complex metabolic changes involved in cancer-associate malnutrition. Transplantable tumors without anti-tumor therapy are useful to reveal catabolic mechanisms, if conducted within the limits of clinically relevant tumor burden. The few studies in which a treatment (surgery, chemotherapy) has been used suggest that malnutrition is the result of tumor-associated processes (capture of substrates; secretion of catabolic factors, alteration of the hormonal environment), of the anti-neoplastic treatments, or of interactions between these. Current approaches in nutritional intervention are focussed on the complex interplay between host and tumor, by the provision of specific amino acids (i.e., arginine, glutamine), as well as polyunsaturated n-3 fatty acids. Feeding route and diet formulation are critical elements of the research approach. Further evolved animal models representing the clinical diversity of cancer and treatments, and the key nutrients, will form a basis to develop the optimal nutritional support for the cancer patient.

Mots clés  : amino acids ; chemotherapy ; fatty acids ; nutrition.




© 2001  Éditions scientifiques et médicales Elsevier SAS. All Rights Reserved.

EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline
You can move this window by clicking on the headline