Systematic review and meta-analysis of the association between psoriasis and metabolic syndrome - 14/09/17
, Herney Andrés García-Perdomo, MD, MSc, EdD, PhD bAbstract |
Background |
Several studies have shown a relationship between psoriasis and metabolic syndrome (MS), but no meta-analysis has been restricted to studies that adjusted for confounders.
Objective |
To determine the association between psoriasis and MS.
Methods |
A systematic review and meta-analysis of observational studies on psoriasis and MS in adults was performed from MEDLINE, Scopus, SciELO, Google Scholar, Science Direct, and LILACS from inception to January 2016. We performed a random effects model meta-analysis for those studies reporting adjusted odds ratios (ORs) with 95% confidence intervals (CIs). The subgroup analysis was related to geographic location, diagnosis criteria and risk of bias.
Results |
In all, 14 papers including a total of 25,042 patients with psoriasis were analyzed. We found that MS was present in 31.4% of patients with psoriasis (OR, 1.42; 95% CI, 1.28-1.65). Middle Eastern studies (in Israel, Turkey, and Lebanon) (OR, 1.76, 95% CI, 0.86-2.67) reported a greater risk for MS than European studies (in Germany, Italy, the United Kingdom, Norway, and Denmark) (OR, 1.40; 95% CI, 1.25-1.55).
Limitations |
Few adjusted studies existed, and there was inconsistency between publications.
Conclusion |
Because of the increased risk for MS, clinicians should consider screening patients with psoriasis for metabolic risk factors.
Le texte complet de cet article est disponible en PDF.Keywords : epidemiology, Europe, Latin America, meta-analysis, metabolic syndrome, Middle East, psoriasis, treatment
Abbreviations used : AHA, ATP III, CI, CVD, DM, HTN, IDF, IL-10, MS, NHLBI, OR, WHO
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
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| Reprints not available from the authors. |
Vol 77 - N° 4
P. 657 - octobre 2017 Retour au numéro
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