Effect of voriconazole on risk of nonmelanoma skin cancer after hematopoietic cell transplantation - 14/09/17
, Bernice Y. Kwong, MD b, ⁎ Abstract |
Background |
Voriconazole has previously been associated with increased risk for cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients. Less is known about the risk in patients after hematopoietic cell transplantation (HCT).
Objective |
We evaluated the effect of voriconazole on the risk for nonmelanoma skin cancer (NMSC), including SCC and basal cell carcionoma, among those who have undergone allogeneic and autologous HCT.
Methods |
In all, 1220 individuals who had undergone allogeneic HCT and 1418 who had undergone autologous HCT were included in a retrospective cohort study. Multivariate analysis included voriconazole exposure and other known risk factors for NMSC.
Results |
In multivariate analysis, voriconazole use increased the risk for NMSC (hazard ratio, 1.82; 95% confidence interval, 1.13-2.91) among those who had undergone allogeneic HCT, particularly for SCC (hazard ratio, 2.25; 95% confidence interval, 1.30-3.89). Voriconazole use did not appear to confer increased risk for NMSC among those who had undergone autologous HCT.
Limitations |
This is a retrospective study.
Conclusion |
Voriconazole use represents an independent factor that may contribute to increased risk specifically for SCC in the allogeneic HCT population.
Le texte complet de cet article est disponible en PDF.Key words : basal cell carcinoma, bone marrow transplantation, hematopoietic cell transplantation, nonmelanoma skin cancer, squamous cell carcinoma, voriconazole
Abbreviations used : BCC, CI, HCT, HR, IR, NMSC, SCC, VNO
Plan
| Drs Weng and Kwong are co-corresponding senior authors. |
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| Support for this project was provided by National Cancer Institute Cancer Center Support Grant 5P30CA124435 and Stanford National Institutes of Health/National Center for Research Resources Clinical and Translational Science Award UL1 RR025744. |
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| Conflict of interest: None declared. |
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| Reprints not available from the authors. |
Vol 77 - N° 4
P. 706-712 - octobre 2017 Retour au numéro
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