La LH participe, avec la FSH, à la croissance folliculaire normale.

LH et follicule ovarien

LH et ovule

Implication de la LH dans les modifications de l'ovocyte, par voie paracrine, par action sur les cellules somatiques à la suite de la stimulation des récepteurs présents sur les cellules de la granulosa.

LH et ovulation

Contrôle de l'ovulation par le pic de LH induisant, en environ 36 heures, la rupture du follicule, la sécrétion de progestérone et la formation du corps jaune.

Activation par la LH d'une cascade pro-inflammatoire lors de la rupture folliculaire et, en retour, d'une cascade anti-inflammatoire pour la cicatrisation de la surface de l'ovaire.

LH participates, with FSH, in normal follicle growth.

LH and the ovarian follicle

• constitutive presence of LH receptors on thecal cells, contribution, in the initial stages of follicle development, to cell proliferation and differentiation, such as FSH receptors, but with androgen instead of estrogen secretion ;
• role of androgens in controlling estrogen production by granulosa cells via paracrine signals during the initial stages of follicle development ;
• expression of LH receptors on granulosa cells at the preovulatory development stage of the follicle with direct intervention of LH in follicle maturation.

LH and the egg

Implication of LH in oocyte modification via paracrine mediation and via the action of somatic cells following stimulation of the receptors present on the granulosa cells.

LH and ovulation

Control of ovulation by the LH peak inducing, about 36 hours later, rupture of the follicle, secretion of progesterone, and formation of the corpus luteum .

Activation of LH by a pro-inflammatory cascade during follicle rupture and, in response, an anti-inflammatory cascade leading to repair of the ovary surface.