Secondary neuroendocrine carcinomas of the skin : An immunohistochemical comparison with primary neuroendocrine carcinoma of the skin (“Merkel cell” carcinoma) - 06/10/17
Résumé |
Since the initial clinical presentation of visceral neuroendocrine carcinoma is occasionally a cutaneous metastasis, diagnostic confusion with primary neuroendocrine carcinoma of the skin (Merkel cell carcinoma) may ensue. In this study, seven cases of secondary cutaneous neuroendocrine carcinoma were immunohistochemieally compared with twenty-one Merkel cell carcinomas for ten antigenic moieties that have been associated with endocrine tumors. Six of seven secondary tumors stained for bombesin, leucine enkephalin, methionine enkephalin, or β-endorphin, none of which was detected in the primary cutaneous neuroendocrine carcinomas. These data suggest that immunohistochemical study may be useful in separating primary from secondary neuroendocrine tumors of the skin and may assist in directing clinical attention to the most probable site of visceral neoplasia.
Le texte complet de cet article est disponible en PDF.Vol 13 - N° 1
P. 134-142 - juillet 1985 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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