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Journal of the American Academy of Dermatology
Volume 14, n° 5P1
pages 770-777 (mai 1986)
Doi : 10.1016/S0190-9622(86)70092-3
accepted : 16 January 1986
Large keratoacanthomas in difficult locations treated with intralesional 5-fiuorouracil

Colleen M. Parker, M.D. , C. William Hanke, M.D.
Department of Dermatology, Indiana University School of Medicine. 

aReprint requests to: Dr. Colleen M. Parker, Department of Dermatology, 1100 West Michigan St., Indianapolis, IN 46223.

Keratoacanthoma is a benign tumor; however, it may cause massive destruction of normal tissue during its rapid growth phase. Intralesional 5-fluorouracil (5-FU) has been shown to be an effective treatment for keratoacanthoma. We have successfully treated five patients with large keratoacanthomas in difficult locations. There have been no recurrences during follow-up periods ranging from 18 to 45 months. Intralesional 5-FU may be ineffective for keratoacanthomas that are not rapidly proliferating.

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