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Journal of the American Academy of Dermatology
Volume 14, n° 5P2
pages 907-909 (mai 1986)
Doi : 10.1016/S0190-9622(86)70110-2
Increased muscle tone during etretinate therapy

Charles N. Ellis, M.D. , ***, **, Martin Gilbert, M.D. *, Kenneth A. Cohen, M.D. *, James W. Albers, M.D., Ph.D. ***, ****, Richard D. Ball, M.D., Ph.D. ****, Roger L. Albin, M.D. ***, Alan Silverman, M.D. *, John J. Voorhees, M.D.
Ann Arbor, MI, USA 

Reprint requests to: Dr. Charles N. Ellis, Dermatology Service (110), Veterans Administration Medical Center, Ann Arbor, MI 48105/ 313-769-7100, ext. 781.

A 40-year-old man with severe psoriasis developed painless muscle stiffness coinciding with four successive courses of etretinate therapy. Peripheral nerve block extinguished the increased muscle tone. Our patient's symptoms resembled those of the stiff-man syndrome. Increased muscle tone is a potential side effect of etretinate treatment and must be distinguished from the common musculoskeletal symptoms observed in patients taking retinoid therapy.

The full text of this article is available in PDF format.

 Supported in part by the Babcock Dermatologie Endowment.

*  From the Clinical Pharmacology Unit of the Department of Dermatology, University of Michigan Medical School
***  the Department of Neurology, University of Michigan Medical School
****  the Department of Physical Medicine and Rehabilitation, University of Michigan Medical School
**  the Dermatology Service, Veterans Administration Medical Center.

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