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Journal of the American Academy of Dermatology
Volume 14, n° 5P2
pages 910-914 (mai 1986)
Doi : 10.1016/S0190-9622(86)70111-4
Keratotic lupus erythematosus: Treatment with isotretinoin

Daniel J. Rubenstein, M.D. 1, Arthur C. Huntley, M.D. , 1
Davis, CA, USA 

*Reprint requests to: Dr. Arthur C. Huntley, M.D., Department of Dermatology, 4301 X St., Sacramento, CA 95817.

We describe a patient with a distinct verrucous variant of chronic discoid lupus erythematosus manifested by skin lesions resembling keratoacanthomas. The diagnosis of keratotic lupus was confirmed by characteristic immunofluorescence and ultrastructural findings and by an initial response to antimalarial therapy. Combination therapy with isotretinoin and hydroxychloroquine resulted in control of her previously refractory skin lesions, and the isotretinoin apparently played a key role in this improvement.

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1  From the Department of Dermatology, University of California at Davis.

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