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Journal of the American Academy of Dermatology
Volume 14, n° 5P2
pages 915-917 (mai 1986)
Doi : 10.1016/S0190-9622(86)70112-6
Subepidermal vesicular dermatosis and sensory peripheral neuropathy caused by pyridoxine abuse

Michael A. Friedman, M.D. *, Jerome S. Resnick, M.D. **, Rudolf L. Baer, M.D. ***
New York, NY, USA 


A woman who had ingested 2 gm of pyridoxine (vitamin B6) daily for 2 years for menstrual water retention developed a subepidermal vesicular eruption on the dorsa of the hands and toes, as well as a sensory peripheral neuropathy. The cutaneous and neurologic manifestations subsided about 2 months after discontinuation of the pyridoxine. The possible relationship of subepidermal vesicular eruptions caused by pyridoxine abuse to epidermolysis bullosa acquisita is discussed.

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*  From the Department of Medicine, Division of Dermatology, Albert Einstein College of Medicine
**  the Department of Neurology, New York Medical College
***  the Department of Dermatology, New York University School of Medicine.

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