Intralesional interferon alfa-2b in the treatment of basal cell carcinoma : Immunohistochemical study on cellular immune reaction leading to tumor regression - 06/10/17
Résumé |
Four patients with basal cell carcinomas were treated with intralesional injections of interferon alfa-2b (1.5 million IU per injection) three times a week for 2 weeks. Histopathologic examination of biopsy specimens of the lesions confirmed the absence of basal cell carcinoma in all cases 4 weeks after completion of therapy. A dense mononuclear cell infiltrate and numerous ectatic blood vessels were present in the dermis at the sites of previous basal cell carcinoma. Immunohistologic analysis of the dermal infiltrate revealed a marked increase of Leu-4+ T cells with a slight predominance of Leu-3+ helper/inducer T cells over Leu-2+ suppressor/cytotoxic T cells. Most of the dermal infiltrate expressed HLA-DR antigen. In addition, Leu-11+ natural killer cells were observed in the dermal infiltrate. Immunohistologic changes in the skin lesions at the sites of previous basal cell carcinoma suggest that intralesional interferon alfa-2b acts on tumor cells by enhancement of local T-cell-mediated immune responses.
Le texte complet de cet article est disponible en PDF. Financial support for reproduction of color illustrations was given by Essex Chemie AG, Lucerne, Switzerland. |
Vol 24 - N° 5P1
P. 731-734 - mai 1991 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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