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Journal of the American Academy of Dermatology
Volume 23, n° 2P1
pages 198-201 (août 1990)
Doi : 10.1016/0190-9622(90)70198-Q
accepted : 29 October 1989
Clinical and laboratory studies

Clinical manifestations in anticardiolipin antibody-positive patients with progressive systemic sclerosis

Ichiro Katayama, MD, PhD , Kazunobu Otoyama, MD, Shigeo Kondo, MD, Kiyoshi Nishioka, MD, PhD, Shigeo Nishiyama, MD, PhD
From the Department of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan 

*Reprint requests: Ichiro Katayama, MD, PhD, Department of Dermatology, Kitasato University School of Medicine, 1-15-1, Kitasato Sagamihara, Kanagawa, Japan.

Anticardiolipin antibody-positive patients with progressive systemic sclerosis were analyzed. Elevated anticardiolipin antibody titers were observed in 13 of 40 cases (33%). Anticardiolipin antibody titer was significantly higher in patients with progressive systemic sclerosis type 1 than in those with type 2 or type 3. Occurrence of anticardiolipin antibody was significantly more frequent in patients positive for anti-nRNP antibodies, rheumatoid factor, or thrombocytopenia. In contrast, patients with proximal scleroderma, scarring, or esophageal hypo-motility were positive for anticardiolipin antibody less frequently. These results suggest that anticardiolipin antibody might be closely associated with lupuslike clinical manifestations in a subset of progressive systemic sclerosis or definite progressive systemic sclerosis with thrombocytopenia, rheumatoid factor, or anti-nRNP antibodies.

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