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Journal of the American Academy of Dermatology
Volume 23, n° 2P1
pages 236-241 (août 1990)
Doi : 10.1016/0190-9622(90)70204-U
accepted : 14 November 1989
Clinical and laboratory studies

Skin pigmentation from clofazimine therapy in leprosy patients: A reappraisal
 

Charles K. Job, MD, FRCPath , 1, Leo Yoder, MD 1, Robert R. Jacobson, MD, PhD 1, Robert C. Hastings, MD, PhD 1
Carville, Louisiana, USA 

*Reprint requests: Charles K. Job, MD, FRCPath, Chief, Pathology Research Department, Gillis W. Long Hansen's Disease Center, Carville, LA 70721.
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Skin biopsy specimens from two lepromatous leprosy patients with dark brown pigmentation who were receiving long-term clofazimine therapy were studied. Ceroid-lipofuscin pigment was demonstrated inside macrophages that contained numerous phagolysosomes. These contained lipids and clofazimine that appeared as electron-lucent vacuoles and a lipofuscin pigment that was electron dense, granular, and lamellated. Although the presence of the drug in tissues contributed to the skin pigmentation, the main cause was a drug-induced, reversible ceroid lipofuscinosis.

The full text of this article is available in PDF format.
1  From Gillis W. Long Hansen's Disease Center. Accepted for publication Nov. 14, 1989.

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