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Journal of the American Academy of Dermatology
Volume 23, n° 2P1
pages 236-241 (août 1990)
Doi : 10.1016/0190-9622(90)70204-U
accepted : 14 November 1989
Clinical and laboratory studies

Skin pigmentation from clofazimine therapy in leprosy patients: A reappraisal

Charles K. Job, MD, FRCPath , 1, Leo Yoder, MD 1, Robert R. Jacobson, MD, PhD 1, Robert C. Hastings, MD, PhD 1
Carville, Louisiana, USA 

*Reprint requests: Charles K. Job, MD, FRCPath, Chief, Pathology Research Department, Gillis W. Long Hansen's Disease Center, Carville, LA 70721.

Skin biopsy specimens from two lepromatous leprosy patients with dark brown pigmentation who were receiving long-term clofazimine therapy were studied. Ceroid-lipofuscin pigment was demonstrated inside macrophages that contained numerous phagolysosomes. These contained lipids and clofazimine that appeared as electron-lucent vacuoles and a lipofuscin pigment that was electron dense, granular, and lamellated. Although the presence of the drug in tissues contributed to the skin pigmentation, the main cause was a drug-induced, reversible ceroid lipofuscinosis.

The full text of this article is available in PDF format.
1  From Gillis W. Long Hansen's Disease Center. Accepted for publication Nov. 14, 1989.

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