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Journal of the American Academy of Dermatology
Volume 23, n° 2P1
pages 242-246 (août 1990)
Doi : 10.1016/0190-9622(90)70205-V
accepted : 1 November 1989
Clinical and laboratory studies

Absence of estrogen receptors in dysplastic nevi and malignant melanoma

M.A. Lecavalier, MD 1, L. From, MD, FRCPC 1, 2, N. Gaid, MD, FRCPC 1
Toronto, Ontario, Canada 


Benign nevi, dysplastic nevi, and primary and metastatic malignant melanomas were evaluated for the presence of sex hormone binding and estrogen receptor protein. We have confirmed the observation of Ellis et al. that some pigmented lesions possess sex hormone-binding proteins. We could not demonstrate a true estrogen receptor in any benign nevi, dysplastic nevi, primary melanomas, or metastatic melanomas. Thus the ability to bind estrogen or progesterone does not correlate with the presence of a true estrogen receptor. Lack of nuclear estrogen receptors suggests that the influence of estrogen on the pathophysiology of melanoma or of benign melanocytic nevi may not be significant.

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1  From the Department of Pathology, Women's College Hospital and Pigmented Lesion Clinic, Toronto Bayview Regional Cancer Centre.
2  L. From, MD, FRCPC, Department of Pathology, Women's College Hospital, 76 Grenville St., Toronto, Ontario, M5S 1B2, Canada.

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