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Journal of the American Academy of Dermatology
Volume 23, n° 2P1
pages 247-249 (août 1990)
Doi : 10.1016/0190-9622(90)70206-W
accepted : 14 November 1989
Clinical and laboratory studies

Neutrophilic dermatosis with myelodysplastic syndrome: Nuclear segmentation anomalies of neutrophils in the skin lesion and in peripheral blood

Naoko Morioka, MD a, , Fujio Otsuka, MD a, Toshitatsu Nogita, MD a, Kyoko Igisu, MD a, Akio Urabe, MD b, Yasumasa Ishibashi, MD a
Tokyo, Japan 

*Reprint requests: Naoko Morioka, MD, Department of Dermatology, Faculty of Medicine, University of Tokyo, 7–3–1 Hongo Bunkyo-ku, Tokyo 113, Japan

Neutrophilic dermatosis developed in two patients with myelodysplastic syndrome. Biopsy specimens of their skin lesions showed marked infiltration by neutrophils with nuclear anomalies, that is, hyposegmentation (pseudo-Pelger-Huët anomaly) or hypersegmentation. Peripheral blood and bone marrow neutrophils had similar anomalies. To our knowledge, this is the first report of nuclear segmentation anomalies of neutrophils in neutrophilic dermatosis skin lesions of patients with myelodysplastic syndrome.

The full text of this article is available in PDF format.
a  From the Department of Dermatology, Faculty of Medicine, University of Tokyo.
b  From the Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.

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