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Journal of the American Academy of Dermatology
Volume 23, n° 2P1
pages 250-254 (août 1990)
Doi : 10.1016/0190-9622(90)70207-X
accepted : 14 November 1989
Clinical and laboratory studies

Localized hyperhidrosis in pretibial myxedema

Daniel G. Gitter, MD 1, Kenzo Sato, MD , 1
Iowa City, Iowa, USA 

Reprint requests: Kenzo Sato, MD, Marshall Dermatology Research Laboratories, Department of Dermatology, University of Iowa College of Medicine, Iowa City, IA 52242.

Two cases of spontaneous hyperhidrosis limited to pretibial myxedema lesions were studied. Quantitative measurements of stimulated eccrine sweat were made after the intradermal injection of methacholine. The sweat rate was two to four times greater in the lesional skin than in perilesional skin. Eccrine secretory glands in excisional biopsy specimens from the pretibial lesions were significantly larger than those in perilesional skin. To our knowledge, hyperhidrosis localized to areas of pretibial myxedema has not been reported.

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* Supported in part by National Institutes of Health grants DK 27857 and HL 32731 and by Cystic Fibrosis Foundation grant R013-9-1.

1  From the Department of Dermatology, University of Iowa College of Medicine.

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