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Journal of the American Academy of Dermatology
Volume 23, n° 2P1
pages 263-268 (août 1990)
Doi : 10.1016/0190-9622(90)70210-9
accepted : 19 October 1989
Clinical and laboratory studies

Platelet activating factor-induced clinical and histopathologic responses in atopic skin and their modification by the platelet activating factor antagonist BN52063
 

Andrew C. Markey, MD a, Jonathan N.W.N. Barker, MD a, Clive B. Archer, MD a, Philippe Guinot, MD c, Tak H. Lee, MD b, , Donald M. MacDonald, MD a
London, England 

*Reprint requests: Prof. T. H. Lee, Department of Allergy and Allied Respiratory Disorders, Hunt's House, 4th Floor, Guy's Hospital, London, SEI 9RT, U.K.
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The clinical and histopathologic responses to intradermal platelet-activating factor (PAF-acether) in atopic subjects, without evidence of atopic dermatitis are documented. An immediate acute wheal and flare reaction was observed in all volunteers. Histopathologically, the reaction was characterized by a predominantly neutrophilic response, which was seen at 30 minutes and was maximal at 4 hours. Eosinophils were observed in the infiltrate as early as 30 minutes after injection, and were maximal by 12 hours. The specific PAF-acether antagonist BN52063 antagonized the acute flare response to intradermal PAF-acether but had little effect on cellular recruitment at the site of injection.

The full text of this article is available in PDF format.
a  From the Department of Dermatology, United Medical and Dental Schools of Guy's and St. Thomas' Hospitals
c  From the Department of Allergy and Allied Respiratory Disorders, United Medical and Dental Schools of Guy's and St. Thomas' Hospitals
b  Ipsen International.

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