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Journal of the American Academy of Dermatology
Volume 4, n° 4
pages 417-422 (avril 1981)
Doi : 10.1016/S0190-9622(81)70040-9
Clinical and Laboratory Studies

Complications of topical hydrocortisone

Jere D. Guin, M.D. 1,
Kokomo, IN, USA 

*Reprint requests to: Dr. Jere D. Guin, 804 South Berkley Road, Kokomo, IN 46901.

Chronic and uninterrupted application of 1% hydrocortisone was followed by complications in six patients. Three developed a rosacea-like eruption for the first time and one also had perioral dermatitis. All of these responded to treatment and remained clear. Another patient had a severe exacerbation of rosacea following use and withdrawal of 1% hydrocortisone cream. Two female adults developed atrophy and telangiectasia of the eyelids following long-term application of 1% hydrocortisone cream. The severity of the complications reported was generally less than that found following use of more potent topical corticosteroids. However, the complications experienced by these patients would suggest that therapy with any effective topical corticosteroid should be intermittent. Particular care should be used in susceptible individuals and in vulnerable areas such as the eyelids.

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1  From the Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN.

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