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Journal of the American Academy of Dermatology
Volume 4, n° 4
pages 458-460 (avril 1981)
Doi : 10.1016/S0190-9622(81)70047-1
Clinical and Laboratory Studies

Lymphocyte kinetics in pustular psoriasis

D.N. Sauder, M.D. , 1, *, W.D. Steck, M.D. 1, P.B. Bailin, M.D. 1, R.S. Krakauer, M.D. 1
Bethesda, MD, USA 

Reprint requests to: Dr. Daniel N. Sauder, National Institutes of Health, National Cancer Institute, Bldg. 10, Room 12, N-238, Bethesda, MD 20205.

Generalized pustular psoriasis is a potentially lethal variant of psoriasis vulgaris characterized by the appearance of sterile pustules on inflamed psoriatic skin. We now report the finding of an absolute lymphopenia at the onset of pustular psoriasis. While the white blood cell count rises to a level of 25,000 to 40,000 in the initial stages of a pustular flare, the lymphocyte count drops from a normal level to an absolute lymphopenia. This “lymphocyte eclipse,” as we have called it, appears to be a reliable sign of impending pustular activity and has now been documented in ten patients with pustular psoriasis. Immediate institution of therapy may abort a potentially lethal complication of psoriasis.

The full text of this article is available in PDF format.

 Presented at the American College of Physicians Meeting, San Francisco, CA, March, 1979.

*  Currently a clinical associate at the National Cancer Institute.
1  From the Departments of Dermatology and Immunology, The Cleveland Clinic Foundation.

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