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Journal of the American Academy of Dermatology
Volume 4, n° 4
pages 461-470 (avril 1981)
Doi : 10.1016/S0190-9622(81)70048-3
Clinical Review

Keloids: A review

John C. Murray, M.D. 1, Sheldon V. Pollack, M.D. , 1, Sheldon R. Pinnell, M.D. 1
Durham, NC, USA 

Reprint requests to: Dr. Sheldon R. Pinnell, Box 3135, Duke University Medical Center, Durham, NC 27710/919-684-5337.

Keloids are predominantly fibrous tumors which appear as firm, variably pruritic or tender growths near a site of injury. Usually appearing between the ages of 10 and 30, most keloids are located on the upper back, shoulders, earlobes, and anterior portion of the chest. The etiology remains unknown, but the accumulated fibrous tissue is associated with increased cellularity and increased metabolic activity of keloid fibroblasts. Isolated keloid fibroblasts demonstrate normal growth characteristics along with increased collagen and proteoglycan synthesis. Numerous keloid treatments have been attempted, but variable success has followed either single use or combinations of intralesional corticosteroid injection, surgery, pressure devices, radiation, cryosurgery, and systemic chemotherapy.

The full text of this article is available in PDF format.

** Supported in part by Grant 2 R01 AM 17128 from the National Institutes of Health and from the Howard Hughes Medical Institute Laboratories at Duke University Medical Center, Durham, NC.
* Publication No. 93 from the Dermatological Research Laboratories of Duke University Medical Center.

1  From the Division of Dermatology, Department of Medicine, Duke University Medical Center.

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© 1981  Published by Elsevier Masson SAS.
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