Diffuse melanosis in metastatic melanoma : Further evidence for disseminated single cell metastases in the skin - 07/10/17
Abstract |
Electron microscopy (EM) and electron microscopic cytochemistry have shown that diffuse melanosis in advanced metastatic melanoma is the result of an unlimited spread of single melanoma cells throughout the dermis; these cells retain their melanogenic capacity and continue to produce melanized melanosomes which eventually are deposited within dermal macrophages and thus impart to the skin a diffuse slate-blue color. These findings are in accordance with previous observations in a similar patient and thus support the concept that single cell metastasis represents a common pathogenic event in these patients.
Le texte complet de cet article est disponible en PDF.* | Supported in part by a grant from the Fonds zur Förderung der wissenschaftlichen Forschung, Vienna (No. 3228). |
Vol 3 - N° 4
P. 363-369 - octobre 1980 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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