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Journal of the American Academy of Dermatology
Volume 4, n° 5
pages 592-596 (mai 1981)
Doi : 10.1016/S0190-9622(81)70062-8
Clinical and laboratory study

Cutaneous extramedullary hematopoiesis presenting as leg ulcers

Tseng-tong Kuo, M.D., Ph.D. 1,
Galveston, TX, USA 

*Reprint requests to: Dr. Tseng-tong Kuo, Department of Pathology, Division of Surgical Pathology, The University of Texas Medical Branch, Galveston, TX 77550.

A case of cutaneous extramedullary hematopoiesis was manifest as bilateral leg ulcers in a patient with myelofibrosis. Six similar cases have been reported previously, although the new case represented an entirely new clinical manifestation. The cutaneous lesions were previously described as erythematous papules, nodules, or plaques. Among these seven cases, myeloid series only or myeloid and erythroid series, with or without megakaryocytes, were found in the cutaneous lesions. All three marrow elements were observed in the ulcers of the present case. The possibility of extramedullary hematopoiesis should be considered in a patient who has myelofibrosis with unusual cutaneous eruptions.

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1  From the Department of Pathology, Division of Surgical Pathology, and the Department of Dermatology, The University of Texas Medical Branch at Galveston.

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