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Journal of the American Academy of Dermatology
Volume 2, n° 4
pages 303-308 (avril 1980)
Doi : 10.1016/S0190-9622(80)80042-9
Clinical and laboratory studies

Multiple hamartoma syndrome : A report of a new case with associated carcinoma of the uterine cervix and angioid streaks of the eyes

Bruce S. Allen, M.D. , Margaret H. Fitch, M.D., J. Graham Smith, M.D.
 From the Department of Dermatology, Medical College of Georgia, USA 

1Reprint requests to: Dr. Bruce S. Allen, Department of Dermatology, Medical College of Georgia, Augusta, GA 30912/404-828-3291.

Multiple hamartoma syndrome is a genodermatosis with autosomal-dominant inheritance. Characteristic findings include mucocutaneous verrucoid papules, “cobblestoning” of the tongue, and hamartomas of multiple organ systems. Also reported are frequent malignancies, especially of the breast. Herein we report a case of a 42-year-old black woman with typical findings of multiple hamartoma syndrome, including an occult malignancy of the uterine cervix, an as yet unreported site of carcinoma in this syndrome. Additionally, we detail a previously unreported finding of bilateral angioid streaks of the optic fundi. Photographs displaying many of the typical features of multiple hamartoma syndrome and associated histopathology are included, along with a brief review of the literature.

The full text of this article is available in PDF format.

* Supported in part by the Medical College of Georgia Research Foundation.

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