Combined methotrexate-PUVA therapy in the treatment of psoriasis - 07/10/17
Résumé |
Thirty patients with psoriasis were treated with a 3-week course of methotrexate followed by a combination of PUVA therapy and methotrexate. When lesions cleared to <1% UVA-exposed body involvement, the methotrexate was stopped and PUVA therapy alone was used as maintenance therapy, This protocol achieved clearance of disease in twenty-eight of the thirty patients in a mean of 5.7 (±1.0) weeks, with 9.3 (±3.0) exposures to PUVA therapy and a final UVA radiation dose at clearance of 6.2 (±2.5) J/cm2 The mean total dose of methotrexate was 93.0 mg (range, 67.5-127.5 mg). The only significant adverse effect seen was prolonged phototoxicity in eight patients. By reducing the total cumulative exposure dose of PUVA therapy, this treatment may reduce long-term side effects.
Le texte complet de cet article est disponible en PDF.| Supported in part by the Arthur O. and Gullan M. Wellman Foundation. |
Vol 6 - N° 1
P. 46-51 - janvier 1982 Retour au numéro
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