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Journal of the American Academy of Dermatology
Volume 4, n° 2
pages 166-175 (février 1981)
Doi : 10.1016/S0190-9622(81)70020-3
Clinical and laboratory studies

Melanocytic nevi in neonates

David N. Silvers, M.D. 1, Elson B. Helwig, M.D. , 2
a New York, NY, USA 
b Washington, DC, USA 

Reprint requests to: Dr. Elson B. Helwig, Skin and GI Pathology, Armed Forces Institute of Pathology, Washington, DC 20306.

The histologic features of seven congenital nevi within 3 months of birth were studied, together with the ultrastructural features of one of the lesions examined microscopically within 48 hours of birth. All seven lesions showed melanocytic hyperplasia within the epidermis and within pilosebaceous and eccrine sweat units. Nevus cells within the dermis were located in proximity to the adnexae. Melanocytic hyperplasia within the epidermis showed a variety of patterns, at least one of which simulated the atypical melanocytic hyperplasia seen in the superficial spreading type of melanoma. The fine structure of the melanosomes in one case studied by electron microscopy resembled hair-bulb melanosomes. They were distinctly different from melanosomes characteristic of epidermal melanocytes, nevus cells, or melanoma cells.

The full text of this article is available in PDF format.

* The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense.

1  From the Departments of Dermatology and Pathology, College of Physicians and Surgeons of Columbia University, New York.
2  From the Skin and Gastrointestinal Pathology Department, Armed Forces Institute of Pathology, Washington.

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