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Journal of the American Academy of Dermatology
Volume 4, n° 2
pages 195-204 (février 1981)
Doi : 10.1016/S0190-9622(81)70023-9
Clinical and laboratory studies

Hypomelanosis of Ito : Report of a case and review of the literature

Jerome W. Buzas, M.D. *, 1, Bahram Sina, M.D. 1, Joseph W. Burnett, M.D. 1
Baltimore, MD, USA 


A 5-month-old boy with hypomelanosis of Ito was studied. Lesions presented as bizarre, hypopigmented whorls and streaks. Histologic studies showed that the hypopigmented areas contained normal melanocytes with decreased content of intracellular melanin. A review of the literature revealed the disease to be a discrete entity of hypopigmentation associated with a high percentage of central nervous system abnormalities, particularly seizure disorders and mental retardation.

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*  Now in the private practice of dermatology, Reading, PA.
1  From the Division of Dermatology, University of Maryland School of Medicine.

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