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Journal of the American Academy of Dermatology
Volume 4, n° 2
pages 239-248 (février 1981)
Doi : 10.1016/S0190-9622(81)70025-2
Special article

Quinacrine hydrochloride drug eruption (tropical lichenoid dermatitis) : Its early and late sequelae and its malignant potential: A review
 

Franz Bauer, M.D. , 1
Melbourne, Victoria, Australia 

*Reprint requests to: Dr. F. Bauer, 100 Collins St., Melbourne 3000, Australia.
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The totality of effects of a particular drug on patients cannot be truly assessed until many patients have taken it. In order to assess the side effects of any drug, many thousands of patients may have to be observed, and the observation may have to extend over decades. Quinacrine hydrochloride (quinacrine) was used as a malarial-suppressive drug by allied soldiers during World War II. The most commonly occurring side effect was a drug eruption. This at times led to permanent sequelae at an early stage. Further observation revealed late sequelae occurring 7 to 17 years after the war. Two of these late sequelae were observed to become malignant, and in most cases the palmar aspect was involved. This is an area which rarely shows malignant change. It has been observed that quinacrine can be instrumental in inducing skin cancers as late as 34 years after its ingestion.

The full text of this article is available in PDF format.
1  From the Department of Veterans' Affairs, Melbourne.

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