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Journal of the American Academy of Dermatology
Volume 3, n° 3
pages 237-240 (septembre 1980)
Doi : 10.1016/S0190-9622(80)80184-8
Clinical and laboratory studies

Dermatoimmunopathology of scabies

Karen Kronman Hoefling, M.D., Arnold L. Schroeter, M.D.
 From the Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, MN, USA 

1Reprint requests to: Dr. A. L. Schroeter, Mayo Clinic, 200 First St. SW, Rochester, MN 55901.

Direct immunofluorescence of scabies lesions revealed IgM, IgA, C3, and fibrin in the cornified layer of the epidermis, dermoepidermal junction, and papillary dermal vessels. The granular deposits of IgM and IgG in the dermoepidermal junction had a pattern similar to that found in lupus erythematosus. These findings support a humoral immune response secondary to scabetic infestation.

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