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Journal of the American Academy of Dermatology
Volume 3, n° 3
pages 244-247 (septembre 1980)
Doi : 10.1016/S0190-9622(80)80186-1
Clinical and laboratory studies

Minocycline and generalized cutaneous pigmentation

James J. Simons, M.D. , Alejandro Morales, M.D.
 From Henry Ford Hospital, USA 

1Reprint requests to: Dr. James J. Simons, Henry Ford Hospital, Department of Dermatology, 2799 W. Grand Blvd., Detroit, MI 48202/313-876-2172.

The recent literature contains sporadic mention of localized pigmentary accumulations in skin, bones, teeth, and thyroid tissue, presumably related to the use of systemic minocycline hydrochloride. It is our purpose to report the occurrence of generalized, cutaneous, dark blue—gray hyperpigmentation that developed in a woman while she was being treated with minocycline (Minocin) for acne vulgaris. We believe this pigmentary change to be minocycline-induced.

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