Melanocyte changes following PUVA therapy - 07/10/17
Résumé |
The effect of psoralens and long-wave ultraviolet light (PUVA) therapy on human melanocytes was studied at the ultrastructural level. The results demonstrate an increase in the number of melanocytes, a change in their location, and an increase in the size of the melanosomes. Significantly, some of the melanocytes extend in narrow columns deep into the dermis, limited by the basal lamina, while others are found free within the dermis. Other morphologic alterations in the melanocytes consist of abnormal mitochondria, a swollen and distorted endoplasmic reticulum, and large lysosomes. The aforementioned abnormalities were also present in PUVA-treated skin that was examined 15 months after the treatment had been stopped.
Le texte complet de cet article est disponible en PDF. Supported by United States Public Health Service Grant I Rol-AM 21681, National Institutes of Health, and by grants from the Phillips Foundation and the McKnight Foundation. |
Vol 1 - N° 5
P. 422-430 - novembre 1979 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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