Proallergens of formaldehyde applied in patch testing of formaldehyde contact allergy - 12/10/17
Résumé |
The ability of the nonliquid, nonvolatile proallergen of formaldehyde, N-hydroxymethylsuacinimide, to test for contact allergy to formaldehyde has been investigated by in vitro penetration studies in human epidermis. Compared with the standard test, 1% formaldehyde in water, N-hydroxymethylsuccinimide equal to 0.8 mg formaldehyde gave a similar penetration profile. This is explained by cleavage of N-hydroxymethylsuccinimide into formaldehyde and carrier (succinimide) by transepidermal water on the surface of the skin. Results were confirmed by a guinea pig maximazation test on animals sensitized to formaldehyde and in a preliminary clinical study on nine patients with known allergy to formaldehyde.
Le texte complet de cet article est disponible en PDF.Vol 21 - N° 4P2
P. 838-840 - octobre 1989 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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