Article

PDF
Access to the PDF text
Advertising


Free Article !

Archives of cardiovascular diseases
Volume 101, n° 6
pages 413-418 (juin 2008)
Doi : 10.1016/j.acvd.2008.05.012
Received : 18 January 2008 ;  accepted : 19 May 2008
Retrograde catheterization of the right heart in patients with occluded femoral veins
Le cathétérisme rétrograde du cœur droit dans les patients avec l’occlusion des veines fémorales
 

Gabriella Agnoletti , Davide Marini, Antoine Legendre, Younes Boudjemline, Damien Bonnet
Service de cardiologie pédiatrique, centre de référence des malformations congénitales complexes M3C, groupe hospitalier hôpital Necker–Enfants-Malades, AP–HP, 149, rue de Sèvres, 75743 Paris, France 

Corresponding author. Fax : +33 1 44 49 57 24.
Summary
Background

Occlusion of the femoral veins is a frequent complication of cardiac catheterization in small children. If the venous femoral approach is not available, a jugular approach is generally used for catheterization of the right heart.

Aims

To describe and evaluate an alternative retrograde approach for catheterization of the right heart in small children with a ventricular septal defect or single ventricle.

Methods

Between January 2004 and January 2007 we attempted retrograde catheterization of the right heart via the femoral artery using a 4 French sheath in eight children with occluded femoral veins. The procedure was planned under awake sedation.

Results

Median age was five months (range 4–60) and median weight was 5kg (range 4–10). Diagnoses were as follows: single ventricle (n =6); pulmonary atresia and ventricular septal defect (n =1); complex transposition of the great arteries (n =1). The procedure was successful in six patients, enabling measurement of pulmonary arterial pressure and pulmonary angiography. The procedure was abandoned in two patients because of ventricular arrhythmias. One patient had concomitant dilatation of aortic recoarctation and one had embolization of aortopulmonary collaterals. With the exception of transient ventricular arrhythmias, no acute or late complications occurred. In particular, transient or permanent atrioventricular block, occurrence of new aortic insufficiency, and acute or late thrombosis of the femoral artery were not observed.

Conclusion

Retrograde catheterization of the right heart in small children is feasible and relatively safe. This technique can be performed without general anaesthesia and avoids a jugular approach.

The full text of this article is available in PDF format.
Résumé
Introduction

L’occlusion des veines fémorales est une complication fréquente du cathétérisme cardiaque pédiatrique. L’abord jugulaire est généralement utilisé quand les veines fémorales sont occluses. Nous décrivons une possible technique alternative qui consiste dans le cathétérisme rétrograde du cœur droit à travers l’artère fémorale chez les petits enfants ayant une communication interventriculaire ou un ventricule unique.

Matériels et méthodes

Pendant la période janvier 2004–janvier 2007, huit enfants avec occlusion bilatérale des veines fémorales ont eu une tentative de cathétérisme rétrograde du cœur droit à l’aide d’un sonde 4F. L’âge et le poids médian étaient de cinq mois (intervalle 4–60) et de 5kg (intervalle 4–10). Les diagnostiques étaient : ventricule unique (n =6) ; atrésie pulmonaire à septum ouvert (n =1) ; et transposition complexe des gros vaisseaux (n =1). L’examen, fait sous sédation, a été complété chez six enfants et a permis de mesurer la pression pulmonaire et de faire une angiographie pulmonaire. Chez deux enfants l’examen a été abandonné à cause d’arythmies ventriculaires. Deux enfants ont eu un geste interventionnel associé (une redilatation d’une recoarctation de l’aorte et une embolisation de collatérales aortopulmonaires). Hormis les arythmies ventriculaires transitoires nous n’avons pas observé de complications immédiates ou tardives, telles que le bloc atrioventriculaire, l’insuffisance aortique et la thrombose de l’artère fémorale canulée.

Conclusions

Le cathétérisme rétrograde du cœur droit est faisable chez les petits enfants ayant une thrombose bilatérale des veines fémorales avec un faible risque. Cette technique peut être faite sous sédation et permet d’éviter l’abord jugulaire.

The full text of this article is available in PDF format.

Keywords : Cardiac catheterization, Paediatrics, Single ventricle, Venous thrombosis, Ventricular septal defect

Mots clés : Cathétérisme cardiaque, Communication interventriculaire, Pédiatrie, Thrombose veineuse, Ventricule unique

Abbreviations : 4F, AP, BT, F, GA, M, PA, PAP, ND, PCPC, RV, TGA, VR, VSD


Introduction

Cardiac catheterization can be performed using an antegrade or a retrograde approach. In general, antegrade catheterization is carried out via the femoral or jugular vein, while retrograde catheterization requires cannulation of the femoral artery. Catheterization of the right heart is usually performed using an antegrade approach. The retrograde approach is often used for radiofrequency ablation of accessory pathways [1, 2] or to close a muscular ventricular septal defect (VSD) [3].

Bilateral thrombosis of the femoral veins is a frequent finding in small children with complex heart disease, who have had repeated cardiac catheterizations or a long stay in an intensive care unit [4, 5, 6]. In these patients, further cardiac catheterization of the right heart is usually carried out via the jugular vein. However, cannulation of the jugular vein can be associated with some risk in small children, especially when it is performed under awake sedation [5, 7, 8].

In our department, diagnostic cardiac catheterization is carried out under awake sedation. When bilateral occlusion of the femoral veins is discovered at the time of catheterization, the examination is rescheduled under general anaesthesia or a retrograde femoral arterial approach is attempted. In this study, we report on the retrograde catheterization of the right heart via the femoral artery in children with a VSD or single ventricle.

Patients and methods

Between January 2004 and January 2007, we attempted retrograde catheterization of the right heart in eight children with occluded femoral veins. In all patients, bilateral thrombosis of the femoral veins was discovered at the time of cardiac catheterization. As the examinations had been planned under awake sedation, transhepatic or jugular approaches were not attempted. Bilateral occlusion of the femoral veins was confirmed by hand injection of a small quantity of contrast medium. Femoral artery access was obtained by using a 4 French (4F) sheath. Heparin was administered at a dose of 100UI/kg. A Judkins right catheter or a balloon-tipped catheter was advanced into the ascending aorta. By using a soft hydrophilic guidewire, the catheter was advanced into the underlying ventricle and positioned immediately under the aortic valve in patients with a subaortic VSD or at the apex of the ventricle in patients with single ventricle and a Norwood-Sano repair. By using hand injection of small quantities of contrast medium and multiples views, the native or artificial pulmonary outflow was localized. The guidewire, then the catheter, were advanced gently into the pulmonary trunk and, when necessary, into the pulmonary arteries. The pressure in the pulmonary artery was measured and pulmonary angiography was performed by injecting contrast medium 1cc/kg at 500psi. All patients had echocardiographic investigation before and after cardiac catheterization. Incompetence of the atrioventricular valve(s) and aorta was sought and described.

Results

The patients’ clinical and hemodynamic characteristics are shown in Table 1. At the time of catheterization, the median age was five months (range 4–60) and the median weight was 5kg (range 4–10). The median duration of the procedure was 45min (range 40–70) and of the fluoroscopy was 10min (range 10–29). The procedure was abandoned in two patients with hypoplastic left heart and Norwood-Sano repair, because of repetitive ventricular arrhythmias, which occurred during attempts to enter the right ventricular outflow; for these patients, haemodynamic evaluation was carried out via the jugular vein under general anaesthesia. In six patients the pulmonary circulation was attained using the retrograde approach, enabling measurement of pulmonary arterial pressure and pulmonary angiography (Figure 1). The superior vena cava was attained in one patient with complex transposition of the great arteries and pulmonary banding, making it possible to calculate the shunt, rule out positive streaming and exclude the persistence of left superior vena cava, suspected at echocardiography (Figure 2).



Figure 1


Figure 1. 

Patient 4 (Table 1). Hypoplastic left heart, having undergone a Norwood-Sano repair. (A) The catheter is advanced through the ascending aorta into the systemic right ventricle; a soft guidewire is advanced into the right pulmonary artery. (B) The anteroposterior view shows symmetrical pulmonary perfusion; pulmonary arteries are mildly hypoplastic. (C) The lateral view shows a tight stenosis at the junction between the conduit and the pulmonary arteries.

Patient 4 (Tableau 1) . Hypoplasie du cœur gauche ayant eu une réparation de Norwood-Sano. (A) Le cathéter atteint de l’aorte ascendante le ventricule unique. Un guide hydrophile est avancé jusqu’à l’artère pulmonaire droite. (B) Chez le même patient l’angiographie pulmonaire montre une perfusion pulmonaire symétrique et des artères pulmonaires un peu hypoplasiques. (C) L’angiographie de profil montre une sténose serrée à la jonction distale du conduit ventricule unique-artère pulmonaire.

Zoom



Figure 2


Figure 2. 

Patient 3 (Table 1). Complex transposition of the great artery, having undergone pulmonary banding. The catheter is advanced from the aorta into the right ventricle, then into the right atrium as far as the innominate vein, showing the absence of the left superior vena cava.

Patient 3 (Tableau 1). Transposition complexe des gros vaisseaux ayant eu un cerclage pulmonaire. Le cathéter a été avancé de l’aorte jusqu’au ventricule droit, l’oreillette droite et le tronc veineux innominé, montrant l’absence d’une veine cave supérieure gauche .

Zoom

Two patients had associated procedures: one patient with pulmonary atresia and a VSD, who had undergone a palliative repair, had embolization of aortopulmonary collateral vessels (Figure 3), and one patient with a Norwood-Sano repair had dilatation of aortic recoarctation. These interventions were possible using the 4F sheath, if the intervention had necessitated a larger sheath or a longer procedural time we would have used the jugular approach under general anaesthesia.



Figure 3


Figure 3. 

Patient 1 (Table 1). Pulmonary atresia and ventricular defect. The right ventricular outflow has been reconstructed and the VSD left open. A balloon catheter is advanced through the ascending aorta into the right ventricle and the pulmonary outflow; pulmonary arteries have normal size and distribution. Occlusion of aortopulmonary collaterals was performed during the same procedure.

Patient 1 (Tableau 1) . Atrésie pulmonaire à septum ouvert. La voie droite à été reconstruite en laissant ouverte le défaut de septum ventriculaire. Un cathéter à ballonnet est avancé de l’aorte au ventricule droit, jusqu’à la voie d’éjection droite. Les artères pulmonaires ont une taille et une distribution normales. Cet enfant a eu une embolisation de collatérales aortopulmonaires pendant le même examen .

Zoom

No acute complications occurred, with the exception of transient ventricular arrhythmias, in particular, no transient or permanent atrioventricular block was observed. Trivial aortic incompetence was present in two patients with Norwood-Sano repair, before and after catheterization (Table 1); the onset of new aortic incompetence was not observed. Acute thrombosis of the femoral artery did not occur; normal femoral pulses were present in all patients at follow-up.

At a median follow-up time of 15 months (range 10–36), four patients had partial cavopulmonary connection and two had biventricular repair. One patient (Patient 5; Table 1), who had elevated mean pulmonary arterial pressure and hypoplastic pulmonary arteries, has not been operated on. One late death occurred two months after cardiac catheterization due to persistent dysfunction of the systemic right ventricle; this patient (Patient 7; Table 1) had undergone dilatation of aortic recoarctation.

Discussion

We have shown that retrograde catheterization of the right heart is a feasible, low-risk procedure in small children. In particular, we did not observe the occurrence of new aortic regurgitation or atrioventricular block.

Catheterization of the right heart is usually achieved using a venous femoral approach. However, if femoral veins are occluded, the jugular approach has been recommended for interventional catheterization of the right heart [9], and for mitral valvuloplasty [10], and is generally performed under general anaesthesia. Cannulation of the jugular vein can be associated with acute and late complications, such as cardiac tamponade [7], puncture of the carotid artery [4, 5] and Horner’s syndrome [8]. We did not attempt a jugular approach, or a transhepatic approach (which can be performed successfully in the presence of occluded femoral veins in small children [11]), because we prefer to use these techniques when general anaesthesia is available.

Electrophysiologists often use retrograde catheterization to ablate accessory pathways as an alternative to transseptal approach [1, 2]. However, several authors have reported that the frequency of occurrence of aortic lesions after retrograde ablation can be as high as 30% [2, 12]. The aortic valve may be injured directly by the catheter tip, when it is passed through the valve or by compression and stretching of the cusps by the catheter shaft during its prolonged placement in the left ventricle [12, 13]. Although the susceptibility of the valvar leaflets may be higher in young patients [13], it seems reasonable to suggest that the risk of valvar injuries from the retrograde aortic approach is in direct relation to the duration of the procedure. Our procedures were of reasonably short duration and the size of our catheter never exceeded 4F; we can assume, therefore, that when these precautions are taken, the risk of aortic valve damage is low.

Although a jugular approach under general anaesthesia is probably less invasive than retrograde catheterization, keeping the atrioventricular valve open is not well tolerated in patients with dysfunction of the systemic ventricle. This condition can be observed in patients with Norwood repair and aortic recoarctation.

Ventricular arrhythmia was the most important complication that we observed in our patients, probably due to the traumatic action of the guidewire while attempting to enter the pulmonary outflow.

In patients who have undergone Norwood-Sano repair, the geometry of the right ventricular outflow can make it difficult to advance the catheter into the pulmonary arteries, in fact, an acute angle can be present at the proximal or distal junction of the right ventricle to pulmonary arteries conduit [14]. Ventricular tachycardia is poorly tolerated in children with single ventricle and, when it occurred, the procedure was abandoned.

Another potential complication of retrograde catheterization is acute or late thrombosis of the femoral arteries [6]. Correct heparinization, strict surveillance after the procedure and aggressive treatment of acute occlusion should avoid thrombosis of the superficial femoral artery. Acute or late occlusion did not occur in our patients.

In conclusion, retrograde catheterization of the right heart can be considered to be a relatively safe option in children with occluded femoral veins and a ventricular septal defect or single ventricle, when the jugular approach with general anaesthesia is not available. Larger studies are required to confirm our preliminary results.

Funding

The authors received no funding for writing this paper.

Conflict of interest

None declared.


Acknowledgement

We thank Patrick Souillard for his assistance in images treatment.

References

Law I.H., Fischbach P.S., LeRoy S., and al. Access to the left atrium for delivery of radiofrequency ablation in young patients: retrograde aortic versus transseptal approach Pediatr Cardiol 2001 ;  22 (3) : 204-209 [cross-ref]
Olsson A., Darpo B., Bergfeldt L., and al. Frequency and long-term follow-up of valvar insufficiency caused by retrograde aortic radiofrequency catheter ablation procedures Heart 1999 ;  81 (3) : 292-296 [cross-ref]
Jameel A.A., Arfi A.M., Arif H., and al. Retrograde approach for device closure of muscular ventricular septal defects in children and adolescents, using the Amplatzer muscular ventricular septal defect occluder Pediatr Cardiol 2006 ;  27 (6) : 720-728 [cross-ref]
Hamilton HC, Foxcroft DR. Central venous access sites for the prevention of venous thrombosis, stenosis and infection in patients requiring long-term intravenous therapy. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD004084. DOI: 10.1002/14651858.CD004084.pub2.
Karapinar B., Cura A. Complications of central venous catheterization in critically ill children Pediatr Int 2007 ;  49 (5) : 593-599 [cross-ref]
Vitiello R., McCrindle B.W., Nykanen D., and al. Complications associated with pediatric cardiac catheterization J Am Coll Cardiol 1998 ;  32 (5) : 1433-1440 [cross-ref]
Al-Azawi O., Shehab R., Ababneh M.O. Cardiac temponade following left internal jugular venous catheterization--a case report Middle East J Anesthesiol 2006 ;  18 (6) : 1161-1164
Ford S., Lauder G. Case report of Horner’s syndrome complicating internal jugular venous cannulation in a child Paediatr Anaesth 2007 ;  17 (4) : 396-398 [cross-ref]
Boudjemline Y., Bonnet D., Sidi D., and al. Closure of extrocardiac Fontan fenestration by using the Amplatzer duct occluder Arch Mal Coeur Vaiss 2005 ;  98 (5) : 449-454
Sullebarger J.T., Coto H., Lopez E., and al. Transjugular percutaneous inoue balloon mitral commissurotomy in a patient with inferior vena cava obstruction after liver transplantation Catheter Cardiovasc Interv 2003 ;  59 (2) : 261-265 [cross-ref]
Ebeid M.R. Transhepatic vascular access for diagnostic and interventional procedures: techniques, outcome, and complications Catheter Cardiovasc Interv 2007 ;  69 (4) : 594-606 [cross-ref]
Minich L.L., Snider A.R., Dick M. Doppler detection of valvular regurgitation after radiofrequency ablation of accessory connections Am J Cardiol 1992 ;  70 (1) : 116-117 [cross-ref]
Lau Y.R., Case C.L., Gillette P.C., and al. Frequency of atrioventricular valve dysfunction after radiofrequency catheter ablation via the atrial approach in children Am J Cardiol 1994 ;  74 (6) : 617-618 [cross-ref]
Kostolny M., Hoerer J., Eicken A., and al. Impact of placing a conduit from the right ventricle to the pulmonary arteries as the first stage of further palliation in the Norwood sequence for hypoplasia of the left heart Cardiol Young 2007 ;  17 (5) : 517-522



© 2008  Elsevier Masson SAS. All Rights Reserved.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline