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Archives of cardiovascular diseases
Volume 110, n° 12
pages 643-645 (décembre 2017)
Doi : 10.1016/j.acvd.2017.08.001
Received : 23 August 2017 ;  accepted : 29 August 2017
Targeting the immune response in atherosclerosis: It's time for clinical trials!
L’immunité innée comme cible thérapeutique dans l’athérosclérose : l’heure des essais cliniques !
 

Figure 1




Figure 1 : 

Immunomodulation of atherosclerosis. Cytokines produced by macrophages, endothelial cells and smooth muscle cells promote local chronic low grade inflammation, leading to atherosclerotic plaque growth and rupture. Neutralizing proinflammatory cytokines or immune cell deactivation through triggering receptor expressed on myeloid (TREM)-1 blockade are promising therapeutic approaches for cardiovascular diseases. IL: interleukin; LDL: low-density lipoprotein; TNF: tumour necrosis factor.

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