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Archives of cardiovascular diseases
Volume 110, n° 12
pages 659-666 (décembre 2017)
Doi : 10.1016/j.acvd.2017.03.008
Received : 1 December 2016 ;  accepted : 23 Mars 2017
Influence of critical closing pressure on systemic vascular resistance and total arterial compliance: A clinical invasive study
Étude clinique invasive de l’influence de la pression critique de fermeture sur la résistance vasculaire systémique et la compliance artérielle totale

Figure 1

Figure 1 : 

The time constant of diastolic aortic pressure decay according to the classic model, which assumes a fixed pressure asymptote=0mmHg in all subjects. Typical exponential decline is superimposed over a schematic aortic pressure curve. The time constant Tau (τ) represents the time necessary for aortic pressure to decrease in value to 36.8% (1/e=0.368) of end-systolic pressure (100%). Assuming a classic Tau value of ∼1.5seconds, it will take theoretically three Tau values (∼4.5seconds) to complete 95% of the pressure change from end-systolic pressure to 0mmHg. Diastolic time at rest is in the <1 second range, i.e. <1 Tau. Thus, the classic model implies a poor use of Windkessel (WK) function at the end of diastole, which is counterintuitive.

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