Definitive radiotherapy for Merkel cell carcinoma confers clinically meaningful in-field locoregional control: A review and analysis of the literature - 14/12/17
Abstract |
Background |
Merkel cell carcinoma (MCC) is an uncommon radiosensitive, neuroendocrine malignancy. Treatment often involves surgery; however, older, sicker patients may not be candidates for an operation. Institutions have published data favoring the role of definitive radiotherapy for macroscopic locoregional disease.
Objective |
Our objective was to report the outcome of patients treated with definitive radiotherapy.
Methods |
We performed a systematic review of Medline, PubMed, and Embase databases for reported cases or series of definitive radiotherapy for macroscopic locoregional MCC.
Results |
The mean radiation dose did not significantly differ between primary and regional sites (48.7 ± 13.2 vs 49.4 ± 10.1 Gy, P = .74). The rate of recurrence was calculated on the basis of the site of disease (11.7%) and per patient (14.3%). Recurrence was significantly more likely to occur at regional than at primary irradiated sites (16.3% vs 7.6%, P = .02). There was no association between radiotherapy dose and incidence of recurrence or nonrecurrence; primary (42.7 ± 23 vs 49.3 ± 11.8 Gy, P = .197) and regional (48.6 ± 10 vs 49.5 ± 10.3 Gy, P = .77).
Limitations |
A limitation of this report is that most publications were retrospective; heterogeneity was present in the size of MCC and in radiotherapy details.
Conclusions |
Definitive radiotherapy for locoregional macroscopic MCC was found to confer clinically meaningful local and regional in-field control.
Le texte complet de cet article est disponible en PDF.Key words : definitive treatment, Merkel cell carcinoma, neuroendocrine, radiotherapy, recurrence
Abbreviations used : Gy, MCC, NCCN
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
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Reprints not available from the authors. |
Vol 77 - N° 1
P. 142 - juillet 2017 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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