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Journal of the American Academy of Dermatology
Volume 77, n° 5
page 938 (novembre 2017)
Doi : 10.1016/j.jaad.2017.06.149
accepted : 28 June 2017

A meta-analysis of nevus-associated melanoma: Prevalence and practical implications

Riccardo Pampena, MD a, Athanassios Kyrgidis, MD a, Aimilios Lallas, MD b, Elvira Moscarella, MD a, Giuseppe Argenziano, MD c, Caterina Longo, MD, PhD a, d,
a Dermatology and Skin Cancer Unit, First Medical Department, Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Reggio Emilia, Italy 
b First Department of Dermatology, Aristotle University of Thessaloniki, Thessaloniki, Greece 
c Dermatology Unit, University of Campania, Naples, Italy 
d Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy 

Correspondence to: Caterina Longo, MD, PhD, Dermatology Unit, University of Modena and Reggio Emilia, Arcispedale Santa Maria Nuova-IRCCS, Viale Risorgimento 80, Reggio Emilia 42100, Italy.Dermatology UnitUniversity of Modena and Reggio EmiliaArcispedale Santa Maria Nuova-IRCCSViale Risorgimento 80Reggio Emilia42100Italy

The reported prevalence of nevus-associated melanoma varies substantially. We performed a systematic review and meta-analysis to determine the incidence and prevalence of this disease; we also performed subanalyses considering age, tumor thickness, and nevus-type classification. In 38 observational cohort and case–control studies, 29.1% of melanomas likely arose from a preexisting nevus and 70.9% de novo. Any given melanoma was 64% less likely to be nevus-associated than de novo (risk ratio 0.36, 95% confidence interval [CI] 0.29-0.44; P  < .001; I2 = 99%); nevus-associated melanomas had a lower mean Breslow thickness than de novo melanomas (mean difference –0.39 mm; 95% CI –0.60 to –0.18; P  = .0003; I2 = 66%). No significant differences were noted regarding the association of nevus-associated melanomas with nondysplastic nevi or dysplastic nevi (risk ratio 0.77, 95% CI 0.49-1.20; P  = .24; I2 = 98%).

The full text of this article is available in PDF format.

Key words : dysplastic nevus, melanoma, meta-analysis, nevus-associated, prevalence, thickness

Abbreviations used : CI, DNM, HR, NAM, RR

 Funding sources: Supported by the Italian Ministry of Health (project code: NET-2011-02347213).
 Conflicts of interest: None declared.
 Reprints not available from the authors.

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