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Journal of the American Academy of Dermatology
Volume 77, n° 5
page 952 (novembre 2017)
Doi : 10.1016/j.jaad.2017.06.041
accepted : 17 June 2017

Atypical features and systemic associations in extensive cases of Grover disease: A systematic review

Madeleine Gantz, MS, MD a, Daniel Butler, MD b, Matthew Goldberg, MD c, Jubin Ryu, MD, PhD d, Timothy McCalmont, MD e, f, Kanade Shinkai, MD, PhD f,
a Drexel University College of Medicine, Philadelphia, Pennsylvania 
b Department of Dermatology, Harvard Medical School, Boston, Massachusetts 
c Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York 
d Department of Dermatology, Palo Alto Medical Foundation, Palo Alto, California 
e Department of Dermatology, University of California, San Francisco, California 
f Department of Pathology, University of California, San Francisco, California 

Reprint requests: Kanade Shinkai, MD, PhD, 1701 Divisadero St, 3rd Floor, San Francisco, CA 94115.1701 Divisadero St, 3rd FloorSan FranciscoCA94115

Grover disease is an acantholytic disorder that typically occurs on the trunk of older individuals, primarily white men, in association with heat and xerosis. Cases with extensive and/or atypical distributions have been reported.


To review the literature characterizing the population, morphology, associations, and disease course of extensive or atypical eruptions of Grover disease.


A systematic literature review identified 50 articles with 69 cases.


Patient age ranged from 14 to 83 years (mean age, 56 ± 15), with 71% of patients being male and 29% female. Areas of involvement included the trunk (90%), upper and lower extremities (63% and 61%, respectively), face/scalp (28%), neck (21%), groin (11%), buttocks (8%), and axillae (6%). The most common associations included a history of malignancy (61%), recent chemotherapy (38%), and recent transplant (20%).


Extensive cases with typical clinical morphology may not have been examined by biopsy or reported; thus, this review may have publication bias toward more severe or atypical presentations.


Greater variability exists among patients affected by extensive or atypical Grover disease than among those with typical disease. Malignancy is a common association, and there may be a role for immunosuppression in the pathogenesis of extensive or atypical Grover disease.

The full text of this article is available in PDF format.

Key words : atypical, extensive, Grover disease, malignancy, toxic erythema of chemotherapy, transient acantholytic dermatosis

Abbreviations used : TEC, UV

 Funding sources: None.
 Conflicts of interest: None declared.
 Aspects of this work were previously presented in poster format at the American Academy of Dermatology Winter Scientific Meeting, Denver, CO; March 21-25, 2014.

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