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Journal of Stomatology Oral and Maxillofacial Surgery
Volume 119, n° 1
pages 33-36 (février 2018)
Doi : 10.1016/j.jormas.2017.10.016
Received : 25 August 2017 ;  accepted : 10 October 2017
Reviews

Paratharmone related protein (peptide): A novel prognostic, diagnostic and therapeutic marker in Head & Neck cancer
 

S. Sen a, P. Dasgupta b, , G. Kamath c, H.S. Srikanth c
a Unit-III, department of surgical oncology, Chittaranjan national cancer institute, 37, S.P. Mukherjee Road, 700026 Kolkata, West Bengal, India 
b Baraniya cooperative society, Flat No. F2, AL/1/C/14, action area 1A, street no. 22, Newrown, 700156 Kolkata, West Bengal, India 
c Department of oral medicine and radiology, Sri Hasanamba dental college and hospital, Vidyanagar, 573202 Hassan, Karnataka, India 

Corresponding author.
Abstract

Parathyroid hormone-related protein (PTHrP) is a promising modality of assessment of different critical features of cancer. It is a protein member of parathyroid hormone family, secreted by certain physiologic cells and by malignant tumors in an increased amount. Recent studies have confirmed that PTHrP massively contributes to malignant behaviour of oral cancers-cell proliferation, migration and invasiveness. Strong correlation was found between PTHrP overexpression and local bone invasion and percentage of tumor cells in metastatic nodes. Normal range of PTHrP in serum is 0.7–2.6ρmol/litre. Its down-regulation blocks cell cycle of cancer cell lines and inhibits cell proliferation and colony formation. PTHrP can be used as a diagnostic aid, prognostic marker and excellent research arena for designing novel anti-neoplastic drugs.

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Keywords : Parathyroid hormone-related protein, Oral squamous cell carcinoma, Cancer, Bone invasion, Osteoclast, Hypercalcemia




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