Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text

Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates

  • You can purchase this item in Pay Per ViewPay per View - FAQ : 30,00 € Taxes included to order
    Pages Iconography Videos Other
    4 0 0 0

Journal of Stomatology Oral and Maxillofacial Surgery
Volume 119, n° 1
pages 33-36 (février 2018)
Doi : 10.1016/j.jormas.2017.10.016
Received : 25 August 2017 ;  accepted : 10 October 2017

Paratharmone related protein (peptide): A novel prognostic, diagnostic and therapeutic marker in Head & Neck cancer

S. Sen a, P. Dasgupta b, , G. Kamath c, H.S. Srikanth c
a Unit-III, department of surgical oncology, Chittaranjan national cancer institute, 37, S.P. Mukherjee Road, 700026 Kolkata, West Bengal, India 
b Baraniya cooperative society, Flat No. F2, AL/1/C/14, action area 1A, street no. 22, Newrown, 700156 Kolkata, West Bengal, India 
c Department of oral medicine and radiology, Sri Hasanamba dental college and hospital, Vidyanagar, 573202 Hassan, Karnataka, India 

Corresponding author.

Parathyroid hormone-related protein (PTHrP) is a promising modality of assessment of different critical features of cancer. It is a protein member of parathyroid hormone family, secreted by certain physiologic cells and by malignant tumors in an increased amount. Recent studies have confirmed that PTHrP massively contributes to malignant behaviour of oral cancers-cell proliferation, migration and invasiveness. Strong correlation was found between PTHrP overexpression and local bone invasion and percentage of tumor cells in metastatic nodes. Normal range of PTHrP in serum is 0.7–2.6ρmol/litre. Its down-regulation blocks cell cycle of cancer cell lines and inhibits cell proliferation and colony formation. PTHrP can be used as a diagnostic aid, prognostic marker and excellent research arena for designing novel anti-neoplastic drugs.

The full text of this article is available in PDF format.

Keywords : Parathyroid hormone-related protein, Oral squamous cell carcinoma, Cancer, Bone invasion, Osteoclast, Hypercalcemia

© 2017  Elsevier Masson SAS. All Rights Reserved.
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Article Outline