Emerging therapies for atopic dermatitis: The prostaglandin/leukotriene pathway - 21/02/18
Abstract |
The role of leukotrienes and prostaglandins in development of atopy has been prototypically established in studies of asthma pathogenesis. Likewise, both in vitro and in vivo studies of atopic dermatitis have demonstrated that these molecules maintain important pathophysiologic roles. Thus, it follows that targeted therapies against these molecules may be promising in management of atopic dermatitis. Montelukast has had questionable efficacy in patients with atopic dermatitis, whereas small pilots using zileuton did have some clinically significant improvement. There are several agents in development that target leukotrienes and/or prostaglandins as well, including OC000459, Q301, and ZPL-521. In atopic dermatitis, OC000459 did not demonstrate efficacy in clinical trials, and the efficacy of the other 2 agents remains to be seen. Should these medications prove promising, these topical agents may play a future role in chronic maintenance therapy and flare prophylaxis in atopic dermatitis, as antileukotriene therapy does in asthma.
Le texte complet de cet article est disponible en PDF.Key words : atopic dermatitis, eicosanoids, leukotrienes, montelukast, pharmacology, prostaglandins, timapiprant, zileuton
Abbreviations used : COX, CPLA2, CRTH2, LT, PG, Th2
Plan
Publication of this article was supported by Leo Pharma, Bayer, and Sanofi/Regeneron. |
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Funding sources: Supported by Bayer, LEO Pharma, and Sanofi. |
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Conflicts of interest: None disclosed. |
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Reprints not available from the authors. |
Vol 78 - N° 3S1
P. S71-S75 - mars 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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