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Archives de pédiatrie
Volume 24, n° S3
pages 5-8 (décembre 2017)
Doi : 10.1016/S0929-693X(18)30037-X
Zika en pédiatrie : que retenir ?
Zika virus in children: an update

P. Minodier
 Urgences enfants, Hôpital Nord, chemin des Bourrelly, 13015 Marseille, France 


Zikavirus (ZV) is a flavivirus transmitted by Aedes mosquitoes’ bites. Sexual transmission is possible. Common ZV infection is asymptomatic or associates flu-like signs. Guillain-Barre syndrome following ZV infection is rare. Foetal infection, during the first trimester of pregnancy especially, can lead to severe neurological troubles. Diagnosis relies on blood and urine RT-PCR during the acute phase, and serology later in the disease. ELISA assays false positives are reported among patients infected with another flavivirus, whereas sero-neutralization is more specific. Treatment is symptomatic. Several vaccines are in the pipeline.

The full text of this article is available in PDF format.

Le virus Zika (ZV) est un flavivirus, transmis par des piqûres de moustiques du genre Aedes . Une transmission sexuelle est également possible. L’infection à ZV est fréquemment asymptomatique ou donne un syndrome grippal banal. Des cas de syndrome de Guillain-Barré au décours de l’épisode infectieux ont été décrits. En cas de transmission trans-placentaire, surtout au 1er trimestre, ZV peut entraîner une fœtopathie avec atteinte neurologique grave. Le diagnostic repose sur l’amplification génique inverse (RT-PCR) (sang et surtout urines) à la phase aiguë, et sur la sérologie plus tardivement. La technique ELISA peut croiser avec d’autres flavivirus. La séroneutralisation est plus spécifique. Le traitement est symptomatique. Plusieurs types de vaccins sont à l’étude.

The full text of this article is available in PDF format.

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