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Archives de pédiatrie
Volume 24, n° S3
pages 5-8 (décembre 2017)
Doi : 10.1016/S0929-693X(18)30037-X
Zika en pédiatrie : que retenir ?
Zika virus in children: an update
 

P. Minodier
 Urgences enfants, Hôpital Nord, chemin des Bourrelly, 13015 Marseille, France 

*Correspondance.
Summary

Zikavirus (ZV) is a flavivirus transmitted by Aedes mosquitoes’ bites. Sexual transmission is possible. Common ZV infection is asymptomatic or associates flu-like signs. Guillain-Barre syndrome following ZV infection is rare. Foetal infection, during the first trimester of pregnancy especially, can lead to severe neurological troubles. Diagnosis relies on blood and urine RT-PCR during the acute phase, and serology later in the disease. ELISA assays false positives are reported among patients infected with another flavivirus, whereas sero-neutralization is more specific. Treatment is symptomatic. Several vaccines are in the pipeline.

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Résumé

Le virus Zika (ZV) est un flavivirus, transmis par des piqûres de moustiques du genre Aedes . Une transmission sexuelle est également possible. L’infection à ZV est fréquemment asymptomatique ou donne un syndrome grippal banal. Des cas de syndrome de Guillain-Barré au décours de l’épisode infectieux ont été décrits. En cas de transmission trans-placentaire, surtout au 1er trimestre, ZV peut entraîner une fœtopathie avec atteinte neurologique grave. Le diagnostic repose sur l’amplification génique inverse (RT-PCR) (sang et surtout urines) à la phase aiguë, et sur la sérologie plus tardivement. La technique ELISA peut croiser avec d’autres flavivirus. La séroneutralisation est plus spécifique. Le traitement est symptomatique. Plusieurs types de vaccins sont à l’étude.

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